n order to be effective, a certain drug must be at amountgreater than 10 mgin the body.The drug is removed from the body with first-order kinetics and ahe half-life is 4.0 hr. (a) (6) If a patient is given a 100 mg dose at midnight, at what time should the patient take another dose such that the concentrationdoes not dip below 10 mg? (b) (4) You discover that the patient ate a grapefruit recently, which inhibits degradation of the drug, reducing the firstorder rate constant by 50%. If you want the drug to be effective for 24 hr(i.e., amount >10 mg), what dosa

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Drug metabolism

In order to be effective, a certain drug must be at amountgreater than 10 mgin the body.The drug is removed from the body with first-order kinetics and ahe half-life is 4.0 hr.

(a) (6) If a patient is given a 100 mg dose at midnight, at what time should the patient take another dose such that the concentrationdoes not dip below 10 mg?

(b) (4) You discover that the patient ate a grapefruit recently, which inhibits degradation of the drug, reducing the firstorder rate constant by 50%. If you want the drug to be effective for 24 hr(i.e., amount >10 mg), what dosage should you give the grapefruit-eating patient?

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