Name and discuss using a representative example, the non-covalent interactions that maintains stability of the double helical structure of DNA.
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Name and discuss using a representative example, the non-covalent interactions that maintains stability of the double helical structure of DNA.
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- State the properties of the WatsonCrick model of DNA in the following categories: a. number of polynucleotide chains b. polarity (running in same direction or opposite directions) c. bases on interior or exterior of molecule d. sugar/phosphate on interior or exterior of molecule e. which bases pair with which f. right- or left-handed helixThe formation of a double-stranded structure must obey the rule that adenine hydrogen bonds to thymine (or uracil in RNA) and cytosine hydrogen bonds to guanine. Discuss reasons why complementarity is an important feature of DNA and RNA structure and function.List three important structural motifs in DNA-binding proteins
- Why is the double-helical structure of DNA stabilized at moderate to high ionic strength?Given the structures of the nitrogenous bases shown in the picture, draw the structure of a part of DNA with the sequence: 5'-GTTCA-3'.Given the structures of the nitrogenous bases below, draw the structure of a part of DNA with the sequence: 5'-GTTCA-3'.
- The adenine derivative hypoxanthine can base-pair with adenine. Draw the structure of this base pair.A duplex DNA molecule contains a random sequence of the four nucleotides with equal proportions of each. What is the average spacing between consecutive occurrences of the sequence 5'-ATGC-3'? Between consecutive occurrences of the sequence 5'-TACGGC-3'?To create a DNA:RNA hybrid from a short stretch of DNA with the sequence 5'-GGCTAAGTATGCCTAGTAGC-3', design the corresponding RNA sequence. Indicate the sequence in a 5' to 3' manner. What type of helix (A, B or Z) will this double-stranded nucleic acid form?
- According to Chargaff's rule of nitrogenous base pairing, which of the following statements is correct? If all adenine bonds to thymine and all cytosine pairs with guanine, then the sum of all adenine will never be equal to the sum of all thymine in a DNA molecule. If all adenine bonds to thymine and all cytosine pairs with guanine, then the sum of all adenine will never be equal to the sum of all thymine in an RNA molecule. If all adenine bonds to thymine and all cytosine pairs with guanine, then the sum of all adenine equals the sum of all thymine in a DNA molecule. If all adenine bonds to uracil and all cytosine pairs with guanine, then the sum of all adenine will never be equal to the sum of all uracil in an RNA molecule.Z-DNA derives its name from the zig-zag conformation of phosphate groups. What features of the DNA molecule allow this structure to form?true or false: Hydrophobic interactions between bases are the primary stabilizing forces responsible for maintaining the DNA double helix.