Neonatal tyrosinemia is due to the deficiency of which of the following enzymes? A. Fumaryl acetoacetate hydrolase B. Tyrosine transaminase C. Tyrosinase D. 4-hydroxyphenylpyruvate dioxygenase
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- Which of the following enzymes possesses a catalytic mechanism extremely similar to that of the Pyruvate Dehydrogenase Complex? A. the isocitrate dehydrogenase B. the succinate dehydrogenase C. the alpha-ketoglutarate dehydrogenase D. the malate dehydrogenaseWhich of the following is correct? A. The gene CYP21A2 is the one that codes for the formation of glucose-6 phosphate dehydrogenase B. Simple virilizing form of Congenital adrenal hyperplasia is the most sever form of this disorder C. Salt wasting type of congenita adrenal hyperplasia is the most severe form of this disorder. D. The gene CYP21A1 is the one that codes for the formation of galactokinase in type 2 galactosemia.Identify the Krebs cycle enzyme that consumes a six-carbon substrate molecule, producing a six-carbon product molecule, but neither consumes nor produces NADH? A. a-ketoglutarate dehydrogenase B. isocitrate dehydrogenase C. succinyl CoA synthetase D. malate dehydrogenase E. aconitase
- which of the following are possible sources of glyceraldehyde 3-phosphate a. more than 1 correct response b. 2 moles of glucos c. cleavage of fructose-1-6-biphosphate d. dihydroxyacetone phosphateWhat are the effects of Glucose-6 Phosphate Dehydrogenase Deficiency? Explain its mechanism of action.Describe the reaction catalyzed by each enzyme: (a) aspartate transaminase; (b) glyceraldehyde 3-phosphate dehydrogenase.
- Indicate what will happen ( increase, decrease or no effect) tothe activity of the enzyme or rate of the metabolic pathway in the given conditions a. release of glucagon in the blood to the activity of carnitine acyl transferase 1 b. high malonyl CoA to the activity of carnitine acyl transferase I C. Epinephrine to the activity og glycogen synthase d. high citrate to the activity of acetyl CoA carboxylase e. high acetyl CoA to ketogenesisMatch the each enzyme deficiency with their corresponding disease β-hexosaminidase A α -galactosidase Sphigomyelinase β-glucosidase A. Fabry disease B. Tay-Sachs disease C. Niemann-Pick disease D. Gaucher diseaseAn "AA" genotype at the ALOX5AP -4900 A>G locus acting in the 5-lipoxygenase pathway may increase risk of breast cancer when intake of which fatty acid is high? a) Stearic acid b) Eicosapentanoic acid c) Linoleic acid d) Alpha-linolenic acid
- Infants do not have the ability to metabolize ethanol and are assumed to lack the enzyme alcohol dehydrogenase? What kind of regulation is this?Statin drugs are used to treat hypercholesterolemia because they a. prevent cholesterol from inserting in plasma membranes b. prevent cholesterol ester formation c. inhibit HMG-CoA reductase d. stimulate HMG-CoA synthaseWhich of the following is NOT a component of the pyruvate dehydrogenase complex? a. dihydrolipoyl dehydrogenase b. dihydrolipoyl transacetylase c. pyruvate dehydrogenase d. dihydrolipoyl catalase