newborn girl appeared normal at birth, but within 24 hours she developed lethargy, hypothermia, and apnea. The attending physician suspects a metabolic disorder and orders a panel of labs. A full blood work up was ordered for this female and the data is presented below. The initial blood ammonia level was elevated at 314 ug/dl (normal range = 17–80) and rapidly rose to 600 ug/dl. Discuss the normal mechanisms of ammonia transfer in the body that should be occurring, including

newborn girl appeared normal at birth, but within 24 hours she developed lethargy, hypothermia, and apnea. The attending physician suspects a metabolic disorder and orders a panel of labs. A full blood work up was ordered for this female and the data is presented below. The initial blood ammonia level was elevated at 314 ug/dl (normal range = 17–80) and rapidly rose to 600 ug/dl. Discuss the normal mechanisms of ammonia transfer in the body that should be occurring, including

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter9: Parenteral Medication Labels And Dosage Calculation

Section: Chapter Questions

Problem 7.6P

See similar textbooks

Similar questions

Propionic acidemia has a relatively high prevalence in South Africa, among both black and white families. This fatal disease is often diagnosed by the elevated presence of propionyl carnitine, propionylglycine and methyl citrate in blood and urine. Discuss the metabolism involved and origin of these markers.
The plasma profiles of codeine (COD) and metabolites for 2 individuals (labeled A and B) are shown below. The X-axis is time in hours after an oral dose of codeine. [M=morphine; C6G=COD-6-glucuronide; M3G = morphine-3-glucuronide; NM (ignore)]. Note the data is shown on a log scale on the Y-axis. (A) Which individual is the poor metabolizer? Explain how you know this from the profiles? (B) Is this a problem for cough suppression? Explain. -CH HO Codeine COD 10 000 1000 C6G COD 100 M3G M6G NM 10 M 10 20 30 0 10 20 30 Plasma concentration (nmol I-)
A 10-week-old child suffered from a salt-wasting crisis. His adrenal glands were enlarged and other organs were normal size. The child is phenotypically female, karotyping showed that the child is 46XY. The biochemical profile shows as: - sodium of 109 (reference range: 134-147) - potassium of 6.1 (reference range: 3.5-5.0) - pregnenlone of 0.002 (reference range: 0.3-1.5) - renin activity of 38 (reference range: 0.5-3.5) - 17-OH pregnenolone of 0.01 (reference range: 6.8-93.5) - ACTH of 1960 (reference range: 0.5-3.5) The cholesterol esters in the adrenal glands accumulated and the concentration of ∆4-androstenedione was not detectable. Also, the enzymes in the steroid biosynthesis did not have detrimental mutations. The child was given treatment with glucocorticoid and mineralocorticoid. Question: a) Which protein is deficient in this case and explain the rationale.
What would happen to the patient if the serum cholinesterase activity were only 10 units of activity per liter rather than the normal activity of about 80 units?
Jyan is 4 months pregnant and requires an IV infusion of magnesium sulfate heptahydrate at a rate of 8 g/hr for 5.6 hours. Magnesium Sulfate Concentrated Injection (2.465 g magnesium sulfate heptahydrate (MgSO4,7H2O MWt = 246.5) in each 5 mL ampoule) is to be diluted with 5% w/v glucose solution to a concentration of 20 %w/v for infusion. What volume of 5% w/v glucose solution is required? (Whole number answer.) Answer is 133 mL Note:please answer the question within two hours
Elevated blood plasma levels of alkaline phosphatase (hyperphosphatasaemia) are an indication of a number of pathologies. Briefly comment on the use of alkaline phosphatase assays as a diagnostic aid for a single common medical condition. (word limit 120 words including citations and references.
Hemoglobin molecules exposed to high levels of glucose areconverted to glycated products. The most common, referred to as hemoglobin A1C (HbA1C), contains a b-chain glycatedadduct. Because red blood cells last about 3 months, HbA1Cconcentration is a useful measure of a patient’s blood sugarcontrol. In general terms, describe why and how HbA1Cforms.
Jyan is 4 months pregnant and requires an IV infusion of magnesium sulfate heptahydrate at a rate of 5 g/hr for 5.3 hours. Magnesium Sulfate Concentrated Injection (2.465 g magnesium sulfate heptahydrate (MgSO4.7H₂O MWt = 246.5) in each 5 mL ampoule) is to be diluted with 5% w/v glucose solution to a concentration of 20 %w/v for infusion. What volume of 5% w/v glucose solution is required? (Whole number answer.)
a 50-year-old woman with a body mass index in the obese range had a weakness in their muscles. she had a history of increased blood pressure but controlled it with medication. the GP has diagnosed her with extreme hypertension and therefore has given her an increased dosage of blood pressure medication but did not have an effect on her hypertension. the biochemical profile shows: - urea of 8.9 (reference range: 2.5-7.0) - sodium of 162 (reference range: 134-147) - potassium of 2.2 (reference range: 3.5-5.0) -aldosterone of 863 (reference range: 90-700) - renin activity of 4.3 (reference range: 0.5-3.5) - aldosterone/RA ratio of 201 (reference range: <680) -cortisol of 511 (reference range: 138-690) -pH of 7.51 ( reference range : 7.35-7.45) Questions: a)what is the medical condition the patient has and what are the causes? fully explain the rationale which is based on the patients history and the test results indicated above. b)which non invasive test will be taken into…
Are statins the best course of treatment for hypercholesterolemia in adults? Why or why not?
A 30-year-old female patient with uncontrolled hypertension is suspected by an investi- gating endocrinologist of having Conn's syndrome. Results of routine biochemistry were (reference ranges are given in brackets): Sodium Potassium Urea Creatinine Alkaline phosphatase Alanine aminotransferase Albumin Bilirubin Calcium 146 mmol/L 2.1 mmol/L 7.2 mmol/L 146 μmol/L 290 IU/L 20 IU/L 49 g/L 8 μmol/L 2.19 mmol/L (135-145) (3.5-5.0) (3.5-6.6) (70-150) (95-320) (5-42) (35-50) (<17) (2.12-2.62) (a) Are any of the electrolyte concentrations abnormal, and if so what condition is suggested? (b) What further biochemistry investigations would you undertake? Explain your reasoning.
If normal plasma pH is 7.4 and normal [CO2) is 1.2 mM, what is the normal (HCO321? The pK9 for this system is 6.1. Phosphoric acid (H3PO4) has three dissociable protons, with the pK,'s shown below. Which form of phosphoric acid predominates in a solution at pH 4? Explain your answer. Acid H3POA 2.14 H2PO4 6.86 HPO,2- 12.4