Introduction to General, Organic and Biochemistry
11th Edition
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Chapter21: Lipids
Section: Chapter Questions
Problem 21.62P
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Question
Draw a stepwise mechanism for the following reaction, one step in the synthesis of the cholesterol-lowering drug pitavastatin, marketed in Japan as a calcium salt under the name Livalo.
Expert Solution
Step 1
Protonation of oxygen atom takes place in the presence of acid H3O+
Hydrogen atom migrates to convert into enol form
Now amine react ith ketone with the elimination of water to get our final product
Step 2
enol form behaves as a nucleophile
Nucleophile attack on electrophile (ketone) given in acidic medium
Step 3
Dehydration of water takes place
Rearrange the molecule
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