Whats the mechanism for the following reaction scheme? OH N3HCINH₂12 (not isolated)as75 °C, 16 h95% (3 steps)11 (not isolated)HN(pyronaridine)OH

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OH N 3HCI NH₂ 12 (not isolated) 11 (not isolated) HN (pyronaridine) ♡° 75 °C, 16 h 95% (3 steps) OH

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter23: Amines

Section23.6: Reactions With Acids

Problem 23.9P

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Question

Whats the mechanism for the following reaction scheme?

OH N
3HCI
NH₂
12 (not isolated)
as
75 °C, 16 h
95% (3 steps)
11 (not isolated)
HN
(pyronaridine)
OH

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