One of your patients, a six-year-old girl who suffers from Sickle cell anemia, an inherited blood disorder in which red blood cells are abnormally shaped and fragile, leading to a short supply of red blood cells. These abnormal cells can also get stuck
Q: A young lady requested pre-marital genetic counselling because her sister had died in infancy of…
A: Gangliosidosis refers to a group of lipid storage illnesses caused by the buildup of lipids called…
Q: The following pedigree shows the inheritance of a human disorder. Affected individuals are shown…
A: A pedigree helps us to determine the inheritance of a trait across generations in a family.
Q: All of these are features of an autosomal recessive pedigree EXCEPT: Heterozygotes have a normal…
A: Pedigree analysis is a form of pictorial representation that depicts medical history and structure…
Q: Please explain why sex linked recessive traits are inherited by the son from his mother. If a mother…
A: Sex Linked Recessive Traits The disease appears almost always in males whose mothers are…
Q: Which of the following disorders in humans has an autosomal dominant inheritance pattern?…
A: Autosomal dominance is an inheritance pattern of some genetic diseases. Autosomal means the gene is…
Q: Cystic fibrosis is an autosomal recessive disorder caused by a defective gene that causes a thick…
A: The genotypic representation for cystic fibrosis can be done as below: CC = Normal, Cc =…
Q: ake the example of B-thalassemia, an autosomal recessive genetic disease that particularly affects…
A: A point mutation is a change in the single nucleotide pair of DNA.
Q: Bloom's Syndrome is an autosomal recessive disorder due to mutations in a helicase protein. Some of…
A: Bloom syndrome is an inherited disorder characterised by low height, a sun-induced skin rash, and a…
Q: Which of the following does not have an autosomal recessivepattern of inheritance?a. cystic…
A: Sir Gregor Mendel was a priest and a teacher who did the famous hybridization experiment on garden…
Q: Canavan disease in an autosomal recessive disorder caused by mutations in the gene that codes for…
A: Given the day disease is an autosomal recessive disorder. We can solve this by assuming that the…
Q: A woman knows that her mother is a carrier of Kartagener’s syndrome (an autosomal recessive…
A:
Q: A blue-eyed man, whose parents were brown-eyed, marries a brown-eyed woman whose father was…
A: Autosomal dominant is a condition found specifically in heterozygotes where the mutant gene is…
Q: Which of the following diseases does not generally follow Mendelian rules of inheritance? breast…
A: Breast Cancer
Q: Martin and Sue are contemplating having children, but Martin’s brother has an autosomal recessive…
A: A trait, disorder, or disease can be passed down through families in several ways. Autosomal…
Q: Thalassemia is an inherited anemic disorder in humans. Affected individuals exhibit either a minor…
A: BASIC INFORMATION THALESSEMIA it is a type of genetic disorder which originated in Mediterranean…
Q: Review the process of autosomal dominant inheritance by coloring the following figures. In this…
A: According to the question, we have to review the process of autosomal dominant inheritance by…
Q: Which of the following mode of inheritance most likely to representthe pedigree showing the pattern…
A: The pedigree is the family tree diagram used to represent the pattern of inheritance in the family.…
Q: Alternate form of the same genes are called
A: The body cells contain pairs of homologous chromosomes. The two chromosomes of each pair have the…
Q: Based on the pedigree, drag a claim about the inheritance pattern of sickle cell anemia into the…
A: Sickle cell anemia : in this disease the RBCs become sickle shaped, due to which the WBCs attack on…
Q: The pedigree shows inheritance of an autosomal recessive disease in an extended family. Assume…
A: Although the trait is skipped in the pedigree, autosomal recessive inheritance is discovered. The…
Q: an example of a condition which is inherited via homozygous genes and one which is heterozygous. Do…
A: Mendel 's three laws sum up the main concepts of Mendelian inheritance: the Law of Independent…
Q: A family from coastal Africa recently moved to Canada. Soon after the move, their 6-month-old baby…
A: The mode of inheritance is a pattern of obtaining parentral alleles or genes to the offsprings. The…
Q: Cystic fibrosis (CF) is an autosomal recessive condition triggered by the overproduction of sticky…
A: Let the dominant allele be represented by C and recessive allele be represented by c. Hence, CC =…
Q: Mendelian Genetics and Non-Mendelian Genetics: Huntington’s disease, a neurodegenerative genetic…
A: Introduction :- Mendelian inheritance or genetics represents the patterns of inheritance that are…
Q: Assuming that no new mutation was present in their daughter, offer a genetic explanation for her…
A: Haemophilia is an X linked recessive disorder. In such cases, males (XY) With one copy of defected…
Q: Bart and Jenny, have been arguing about the cause of their baby's aneuploid condition. Bart was 5…
A: X Linked Inheritance When the disease-causing gene or allele is present on the Sex chromosome…
Q: Xeroderma pigmentosum (XP) is a human disease which is autosomal recessive. It is a genetic mutation…
A: Xeroderma pigmentosum (XP) is a human disease which is autosomal recessive. woman who is a carrier…
Q: Huntington’s disease is an autosomal dominant disease in humans, but the first symptoms usually…
A: Autosomal dominant disorder inheritance The dominant autosomal mutated gene cause the defect in…
Q: You met with two parents whose first child has sickle cell anemia. (The parents show no signs of the…
A: The mutation in a single gene results in Mendelian disorders. There are five types of Mendelian…
Q: The following image shows Nondisjunction. Which of the following cells will suffer from a genetic…
A: Nondisjunction is a failure of chromosomes to separate during cell division. This results in the…
Q: There are six types of agglutinogen named C,D, E and c,d,e.the first three are dominant and last…
A: In blood typing, antigens on the surfaces of red blood cells (RBCs) are known as agglutinogens.…
Q: The attached image is a pedigree of a family with a history of sickle cell anemia (the individuals…
A: Sickle cell anemia is a genetic condition caused by a mutation in the gene that codes for…
Q: Your brother has an autosomal recessive disorder, while you are unaffected. Neither one of your…
A: Question - Your brother has an autosomal recessive disorder, while you are unaffected. Neither one…
Q: (a) What percentage of their children are likely to have a disease phenotype? (b) What percentage…
A: Carrier Genotype A person who carries affected gene but not affected by that disorder because of…
Q: Hutchinson-Gilford syndrome, is an extremely rare, progressive genetic disorder that causes children…
A: Mutations in the LMNA gene cause Hutchinson-Gilford progeria syndrome. Here, we have to select the…
Q: ystic fibrosis (CF) is an autosomal recessive condition triggered by the overproduction of sticky…
A: Suppose the alleles affecting CFTR protein formation are AA, aa being homozygous recessive and hence…
Q: The pedigree shows inheritance of an autosomal recessive disease in an extended family. Assume…
A: Autosomal recessive inheritance is found because the trait is skipped in the given pedigree. Let A…
Q: sive disorder found on the X chromosome. There can be individuals that are carriers for the trait…
A: X linked Recessive Disorder: Genetic problems related with mutations in genes on the X chromosome…
Q: Hereditary hemochromatosis is an autosomal recessive genetic disorder that causes the body to absorb…
A: Within organisms, many various forms of mutations occur, and depending on the type of mutation, it…
Q: Cystic fibrosis (CF) is an autosomal recessive condition triggered by the overproduction of sticky…
A: Cystic fibrosis is encoded by autosom recessive inheritance. Let C allele encodes normal phenotype.…
Q: ABO blood groups, an autosomal trait, in Humans are genetically determined. A woman with type O…
A: SOME BASIC INFORMATION USED IN GENETICS MODES OF INHERITENCE 1. AUTOSOMAL DOMINANT INHERITENCE In…
Q: A man with the sickle cell trait married a woman with the sickle cell trait. Determine the…
A: Individuals having HbA allele show normal cells in homozygous form and in heterozygous form of…
Q: Albinism and sickle cell anemia are both autosomal recessive disorders that are expressed only in…
A: Father genotype:- AaSs Mother's genotype:- AaSs Aa-Albinism carrier Ss-Sickle cell anemia carrier…
Q: Albinism in humans is autosomal and fully recessive to normal color. A couple, who are both normal,…
A: Albinism is an autosomal recessive disorder which means that only homozygous recessive genotype will…
Q: Sickle cell anemia is a disease that is caused by a mutation in the gene that produces hemoglobin.…
A: HbA allele encodes normal hemoglobin. Whereas HbS allele encodes sickle cell hemoglobin.
Q: The above pedigree represents the inheritance of a disease that is most likely Autosomal Dominant O…
A:
Q: Cystic fibrosis (CF) is an autosomal recessive condition triggered by the overproduction of sticky…
A: In autosomal recessive disorder, two copies of altered gene are required to cause the disease. The…
Q: What is autosomal cells
A: The autosomes are non gender specific chromosomes or it is not related to sex chromosome. The…
One of your patients, a six-year-old girl who suffers from Sickle cell anemia, an inherited blood disorder in which red blood cells are abnormally shaped and fragile, leading to a short supply of red blood cells. These abnormal cells can also get stuck in small vessels, which prevent blood flow, leading to fatigue, pain and other severe complications.
Sickle cell anemia is an autosomal recessive disorder. Neither of your patient's parents has sickle cell anemia. What is the most likely genotype of her parents? (The normal beta-globin allele is abbreviated as B, and the abnormal allele as b.)
Step by step
Solved in 2 steps
- A couple is planning a family, but since each has a brother having the sickle-cell disorder, they are worried that their kids might develop the disorder too. Neither of them nor their respective parents have the disorder. Which of the following will be your smartest advice as a genetic counsellor? One of four of their children can be expected to have sickle cell. It is possible that none of their kids will have the disorder, but tests should be carried out on both of them to confirm. All of their children will have sickle-cell disorder. There is no chance of any of their kids having sickle cell.Huntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Mary is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Paul whose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibits sickle cell anemia. What are the genotypes of Jane and Paul? If they plan to have four children, what is the probability that: all their children will be normal? _________________________________ they will have a son with Huntington’s disease? _________________________ they will have a daughter inflicted with both conditions?________________Huntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Jane is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Paul whose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibit sickle cell anemia. What are the genotypes of Jane and Paul? If they plan to have four children, what is the probability that: all their children will be normal? _________________________________ they will have a son with Huntington’s disease? _________________________ they will have a daughter inflicted with both conditions?________________
- Huntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Jane is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Paul whose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibit sickle cell anemia. What are the genotypes of Jane and Paul? Jane:______________________________Paul:_____________________________ If they plan to have four children, what is the probability that: all their children will be normal? _________________________________ they will have a son with Huntington’s disease? _________________________ they will have a daughter inflicted with both conditions?________________Huntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Jane is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Paul whose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibits sickle cell anemia. What are the genotypes of Jane and Paul?Sickle cell anemia is caused by an individual carrying two recessive copies of the hemoglobin gene (hemoglobin gene is labeled Hb, and the recessive version is Hbs). Thus, to have sickle cell anemia, a person must have the genotype HbSHbS. A person that is HbAHbA carries two copies of the normal hemoglobin gene and does not have sickle cell anemia. A person that is heterozygous (HbAHbS) produces enough normal hemoglobin to not have sickle cell anemia but is also resistant to malaria. People that are heterozygous are called “carriers” because they carry the recessive allele but do not express the recessive phenotype. a. A couple are both resistant to malaria but do not have sickle cell anemia. Draw a Punnett square to represent this cross. b. What is the probability that the couple has three children where one child does not have a recessive allele, one child is resistant to malaria and does not have sickle cell anemia, and one child has sickle cell anemia?
- Sickle-cell disease is an autosomal recessive genetic disorder. How many mutated hemoglobin alleles do people with sickle-cell disease have?Huntington’s disease is an autosomal dominant disease in humans, but the first symptoms usually don’t appear until after the age of 30. If Aethelbert inherited one copy of this gene from his mother, what is the chance of him passing it on to his children?The attached image is a pedigree of a family with a history of sickle cell anemia (the individuals with the filled-in symbols have the disease and no new mutations are occurring in any individual). Sickle cell anemia is inherited in an autosomal recessive manner. What is the probability that the individual with the question mark (?) will get the disease? a) 1/4 b) 1/2 c) 2/3 d) 1
- Porphyria is a genetic disorder caused by the inability to properly metabolize a component of hemoglobin. King George III is suspected to have been afflicted with this disorder. Assume that both George and his Queen suffered from this disorder and they had one afflicted child and one normal child. Is porphyria inherited in a dominant or recessive fashion? What must be the genotype of both George and his Queen? Using punnett square, show ALL work used to achieve your answer.Victoria’s youngest child, Beatrice, gave birth to one daughter, one normal son, and two hemophilic sons. **Based on the pedigree, Alfonso XIII of Spain is phenotypically normal. Does that mean he received the normal gene from Beatrice? Why or Why not?**Hereditary hemochromatosis is an autosomal recessive genetic disorder that causes the body to absorb too much iron from the diet. This excess iron is stored in the body's tissues and organs, particularly the skin, heart, liver, pancreas, and joints. Because humans cannot increase the excretion of iron, excess iron can overload and eventually damage tissues and organs. A man who had hemophilia (an X-linked recessive genetic disorder), married a woman who had no family history of hemophilia whatsoever. The couple had consulted a genetic counselor when they first contemplated having children due to concerns that their future children might have hemophilia. Genetic testing of both future parents revealed that the husband did, in fact, possess the Hemophilia A allele but his wife was completely normal with respect to hemophilia. Much to their shock, their first child, a daughter, had a mild blood clotting disorder. Karyotyping was performed to determine whether this daughter had an…