The following three derivatives of succinimide are anticonvulsants that have found use in the treatment of epilepsy, particularly petit mal seizures.Q. Describe the chemistry involved in the conversion of (B) to (C). You need not present detailed mechanisms. Rather, state what is accomplished by treating (B) with NaOH and then with HCl followed by heating. PhPhCH3ČH3MethsuximideEthosuximidePhensuximide(racemic)(racemic)(racemic)Following is a synthesis of phensuximide.CNPh CHO +PhKCNPhCNCNNaOEt1. NaOH, H,OHNÓ2. НС, Н,оCOOE 3. heatCOOEtCOOELBenzal-Ethyldehyde cyanoacetate(A)(В)(гасеmie)PhPhPhCH,NHHOOCСООНELOOCCOOEt'N'(C)(racemic)(D)(racemic)ČH3Phensuximide(racemic)

Cyanide ion will get converted into carboxylic acid in the presence of NaOH and water or it is…

Answered: Ph Ph CH3 ČH3 Methsuximide Ethosuximide…

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter20: Carbohydrates

Section: Chapter Questions

Problem 20.28P

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The following three derivatives of succinimide are anticonvulsants that have found use in the treatment of epilepsy, particularly petit mal seizures.

Q. Describe the chemistry involved in the conversion of (B) to (C). You need not present detailed mechanisms. Rather, state what is accomplished by treating
(B) with NaOH and then with HCl followed by heating.

Ph
Ph
CH3
ČH3
Methsuximide
Ethosuximide
Phensuximide
(racemic)
(racemic)
(racemic)
Following is a synthesis of phensuximide.
CN
Ph CHO +
Ph
KCN
Ph
CN
CN
NaOEt
1. NaOH, H,O
H
NÓ
2. НС, Н,о
COOE 3. heat
COOEt
COOEL
Benzal-
Ethyl
dehyde cyanoacetate
(A)
(В)
(гасеmie)
Ph
Ph
Ph
CH,NH
HOOC
СООН
ELOOC
COOEt
'N'
(C)
(racemic)
(D)
(racemic)
ČH3
Phensuximide
(racemic)

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