Pilocarpine is a medication used in eye drop to manage angle closure glaucoma. It works by activating cholinergic receptors of the muscarinic type which cause the trabecular meshwork to open and the aqueous humor to drain from the eye. The diester compound in the left can serve as a prodrug for pilocarpine. Please provide a mechanism for this conversion using esterase.

Pilocarpine is a medication used in eye drop to manage angle closure glaucoma. It works by activating cholinergic receptors of the muscarinic type which cause the trabecular meshwork to open and the aqueous humor to drain from the eye. The diester compound in the left can serve as a prodrug for pilocarpine. Please provide a mechanism for this conversion using esterase.

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter11: Ethers, Epoxides, And Sulfides

Section: Chapter Questions

Problem 11.38P

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