Please explain Androgen Insensitivity Syndrome (ALS). What is the phenotype of these individuals? What is their chromosomal makeup?Why does this disorder occur?
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- Under what conditions does a female acquire anX-linked recessive disorder?Incontinentia pigmenti, a rare, X-linked dominant disorder inhumans, is characterized by swirls of pigment in the skin. If anaffected female, who had an unaffected father, has children with anunaffected male, what are the predicted ratios of affected andunaffected sons and daughters?If a woman is heterozygous for neurofibromatosis (a dominant disorder) and produces with a homozygous normal man for the disorder, what are the chances that a child will have the disorder?
- Can a woman who is affected by an X-linked dominant disorder have a child who is not affected? Why or why not?Discuss whether the following individuals (1) have male or female gonads, (2) are phenotypically male or female (Wolffian or Muellerian ducts. External genitalia) and (3) are sterile or fertile. a) XY, homozygous for a recessive mutation in the testosterone biosynthetic pathway, producing no testosterone b) XX, heterozygous for a dominant mutation in the testosterone biosynthetic pathway, which causes continuous production of testosteroneCharles has achondroplasia dwarfism (autosomal dominant) but his wife is normal. What is the likelihood that they will have a child with achondroplasia dwarfism? What is the likelihood that they will have embryos that will die from achondroplasia dwarfism? Please explain.
- If a genetic female fetus is exposed to testosterone in utero, would that individual develop a complete male phenotypic sex, partial male phenotypic sex, or a normal female phenotypic sex? Explain your answer, describing the sex phenotype of the gonads, internal genital ducts and external genitalia. What would the developmental outcomes be if the fetus were instead exposed to dihydrotestosterone in utero?An individual that is genetically male develops as a female. Is this individual more or less likely to express an X-linked recessive disorder than an average female?What will be the sex of an individual who is easily affected by an X-linked recessive trait? Why?
- X-linked disorders (like hemophilia) are more likely to affect people of one gender than the other. Which gender is this, and why are x-linked disorders more likely to affect people of this gender?Explain the difference between X-linked recessive traits and X-linked dominant traits. What are the possibilities that a female child will be affected and express each of the traits?What is a monogenic disease?