Please explain the Chemistry behind the synthesis process of Sulfonamides.I badly need help, thank you so much. EulfenamideFAITH M. POLICARPIO(ELECTRON-FLOW MECHANISM)• BENZENE TO NITROBENZENENO2NO2NO2NO2(HNO3/HeS04)ON-NO2-H*• NITROBENZE TO ANILINEDH+2e,t2H*.(Sn/ HCI)-Heo.+2e, 2H+Sn/HCIHO-+2e, +2H-H20H.• ANILINE TO ACETANILIDECHSNH2HzNNHCOCH3CHSCOOHCH3C.-CH3COOH+ CHs• ACETANILIDE TO 4-ACETAMEDOBENZENE SULFONYL CHLORIDENHCOCH3NHCOCHSCISOSHH*-H20OHOHNHCOCHSNHCOCH3NHCOCH3NHCOCH3HSO,CI•4-ACETAMEDO BENZENE SULTONYL CHLORIDE TO 4-ACETAMEDO BENZENE SUL FONAMIDENHCOCH3NHCOCH3NHCOCH,NH3H--CINH2ŠO NH,• 4-ACETAMEDO BENZENESULFONAMIDE TO SULFONAMIDEO OHC:HO:HN-CH3HN-CH3HN-CH3OHH°HzöH20/HCI„H.ŠO, NH2SO, NH2SO̟NHNH2i> -H*ii>+H*+ CH,COOHSO-NH2

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Answered: Please explain the Chemistry behind the…

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Chemistry

Please explain the Chemistry behind the synthesis process of Sulfonamides.

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter20: Dienes, Conjugated Systems, And Pericyclic Reactions

Section: Chapter Questions

Problem 20.48P

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Please explain the Chemistry behind the synthesis process of Sulfonamides.

I badly need help, thank you so much.

Eulfenamide
FAITH M. POLICARPIO
(ELECTRON-FLOW MECHANISM)
• BENZENE TO NITROBENZENE
NO2
NO2
NO2
NO2
(HNO3/
HeS04)
ON
-
NO2
-H*
• NITROBENZE TO ANILINE
DH
+2e,t2H*.
(Sn/ HCI)
-Heo.
+2e, 2H+
Sn/HCI
HO-
+2e, +2H
-H20
H.
• ANILINE TO ACETANILIDE
CHS
NH2
HzN
NHCOCH3
CHSCOOH
CH3
C.
-CH3COOH
+ CHs
• ACETANILIDE TO 4-ACETAMEDOBENZENE SULFONYL CHLORIDE
NHCOCH3
NHCOCHS
CISOSH
H*
-H20
OH
OH
NHCOCHS
NHCOCH3
NHCOCH3
NHCOCH3
H
SO,CI
•4-ACETAMEDO BENZENE SULTONYL CHLORIDE TO 4-ACETAMEDO BENZENE SUL FONAMIDE
NHCOCH3
NHCOCH3
NHCOCH,
NH3
H-
-CI
NH2
ŠO NH,
• 4-ACETAMEDO BENZENESULFONAMIDE TO SULFONAMIDE
O OH
C:
HO:
HN-
CH3
HN-
CH3
HN-
CH3
OH
H°
Hzö
H20/HCI
„H.
ŠO, NH2
SO, NH2
SO̟NH
NH2
i> -H*
ii>+H*
+ CH,COOH
SO-NH2

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