Please help with this homework assignment See image/PDFhttps://static.nsta.org/case_study_docs/case_studies/gwas_studies.pdfPart 3 What other factors will alter Josie’s risk of developing Alzheimer’s disease?Based on Josie’s genotype, what dose of warfarin would be best for her (high, low, or intermediate dose)?One of Josie’s favorite vegetables is asparagus. She noticed that she could detect a strong sulfur smell in her urine after eating asparagus. Explain why she is able to do this after looking at her data. Part III - Lab ResultsBelow is a partial list of Josie's results showing the gene that was tested, the chromosomal location of each gene and thegenotype of the SNPs within that gene.ReportVariant testedAPOE (rs429358)(rs7412)VKORI (rs9923231)CYP2C9 2 (rs1799853)CYP2C9 3 (rs1057910)Marker rs4481887ALDH2 (rs671)GenotypeCTCCAACCACAAAGChromosomal Location191916NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE101012"Living in a Genomic World" by Glaser and ZimmerPhenotype/RiskQuestions1. Using the information you learned about the various traits in Part II, fill in the final column of the chart above bydetermining Josie's phenotype or risk based on her genotype. Explain how you interpreted the results.a. What other factors will alter Josie's risk of developing Alzheimer's disease?b. Based on Josie's genotype, what dose of warfarin would be best for her (high, low, or intermediate dose)?c. One of Josie's favorite vegetables is asparagus. She noticed that she could detect a strong sulfur smell in herurine after eating asparagus. Explain why she is able to do this after looking at her data.d. By looking at the data, what does Josie's genotype tell you about her sensitivity to alcohol? Should thisinformation result in any behavior modifications?2. Typically, genomic testing services group the traits they test for into categories such as (1) recessive disorders, (2)drug response, (3) risk factors, and (4) non-health related traits. Consider the four traits mentioned in Part II(Alzheimer's disease, warfarin sensitivity, asparagus metabolite detection, and alcohol flush reaction). In whichcategory does each trait belong?3. Would you have liked to know your APOE status regardless of the results? Why or why not?4. Do you think that Josie should be obligated to tell her family members the results? Why or why not? Would youfeel differently based on different APOE results? Would you feel differently if you were a carrier for a recessivedisease? If you had the allele for Huntington's disease, an autosomal dominant disorder characterized by progressiveneurodegeneration?Page 10

Alzheimer's disease is a progressive neurodegenerative disorder that affects the brain, leading to…

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1st Edition

ISBN:9781938168130

Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble