Q-7. Receptor Mediated Endocytosis a. Which protein depicted is a small monomeric GPTase? b. Are all vesicle coats made of Clathrin? Explain. c. Are all adaptins alike? d. Clathrin triskelions self- assemble upon binding a cargo-receptor-adaptin complex. What causes them to diassemble at the end when the vesicle gets pinched off? e. This diagram depicts endocytosis, does the same mechanism apply to the secretory pathway (in reverse?)

Q-7. Receptor Mediated Endocytosis a. Which protein depicted is a small monomeric GPTase? b. Are all vesicle coats made of Clathrin? Explain. c. Are all adaptins alike? d. Clathrin triskelions self- assemble upon binding a cargo-receptor-adaptin complex. What causes them to diassemble at the end when the vesicle gets pinched off? e. This diagram depicts endocytosis, does the same mechanism apply to the secretory pathway (in reverse?)

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter5: Structure And Function Of Plasma Membranes

Section: Chapter Questions

Problem 32CTQ: The sodium/calcium exchanger (NCX) transports sodium into and calcium out of cardiac muscle cells....

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25. For a Paramecium shifted from from a hypo-osmotic to an iso-osmotic environment, you would expect the activity of its contractile vacuole to .... a) increase. b) decrease. c) remain unchanged.
The sodium/calcium exchanger (NCX) transports sodium into and calcium out of cardiac muscle cells. Describe why this transporter is classified as secondary active transport.
Ion transporters are “linked” together—not physi-cally, but as a consequence of their actions. For example,cells can raise their intracellular pH, when it becomes tooacidic, by exchanging external Na+ for internal H+, usinga Na+–H+ antiporter. The change in internal Na+ is thenredressed using the Na+-K+ pump.A. Can these two transporters, operating together,normalize both the H+ and the Na+ concentrations insidethe cell?B. Does the linked action of these two pumps causeimbalances in either the K+ concentration or the mem-brane potential? Why or why not?
a) Give the two main membrane proteins.b) State a function each of the mentioned protins. c) Explain why change in pH can affect the function of the proteins.
Progression through the cell cycledepends on the phosphorylationof hundreds of different proteins bycyclin–Cdk complexes. What are themolecular mechanisms ensuring thatthese proteins are phosphorylated atprecisely the right time and place?
Membrane embedded Proteins: A) Why were the membrane embedded proteins important in the appearance of life? B) Why was it important to have a mechanism for the movement of molecules in to and out of the cell? C) Describe the key structure and functional properties of the three types of cell membrane embedded transport proteins.
During apoptosis, phosphatidylserine undergoes transverse movement (flip-flop). Explain why this could help identify apoptotic cells to phagocytic cells for engulfment and disposal.
It is not an easy matter to assign particular func-tions to specific components of the basal lamina, sincethe overall structure is a complicated composite materialwith both mechanical and signaling properties. Nidogen,for example, cross-links two central components of thebasal lamina by binding to the laminin γ-1 chain and totype IV collagen. Given such a key role, it was surprisingthat mice with a homozygous knockout of the gene fornidogen-1 were entirely healthy, with no abnormal phe-notype. Similarly, mice homozygous for a knockout of thegene for nidogen-2 also appeared completely normal. Bycontrast, mice that were homozygous for a defined muta-tion in the gene for laminin γ-1, which eliminated just thebinding site for nidogen, died at birth with severe defectsin lung and kidney formation. The mutant portion of thelaminin γ-1 chain is thought to have no other functionthan to bind nidogen, and does not affect laminin struc-ture or its ability to assemble into the basal lamina.…
33. Which statements concerning passive and active transport are correct? A. Both passive and active transport requires cell energy B. Passive requires cell energy while active transport does not C. Active transport requires cell energy while passive does not D. Neither passive nor active transport requires cell energy
Even under isotonic conditions, there is a slow leakage of ions into animal cells. How does the plasma-membrane Na+/K+ ATPase enable animal cells to avoid osmotic lysis under isotonic conditions?
Which statements are true? Explain why or why not.1 Given the numerous processes inside cells thatare regulated by changes in Ca2+ concentration, it seemslikely that Ca2+-dependent cell–cell adhesions are alsoregulated by changes in Ca2+ concentration.2 Tight junctions perform two distinct functions:they seal the space between cells to restrict paracellularflow and they fence off plasma membrane domains toprevent the mixing of apical and basolateral membraneproteins.3 The elasticity of elastin derives from its high con-tent of α helices, which act as molecular springs.4 Integrins can convert mechanical signals intointracellular molecular signals.
Which transport mechanism can bring whole cells into a cell? pinocytosis phagocytosis facilitated transport primary active transport