Q5.1. Which of the following is FALSE? • If a genetic disease reduces fertility and the allele that causes the disease offers no other advantage, the allele will likely eventually disappear, due to natural selection. • Natural selection does not favor individuals who are homozygous for the sickle-cell allele, because these individuals typically die before they are old enough to reproduce. Individuals who are heterozygous HbA/HbS are protected from malaria, and this is why sickle-cell disease persists in wetter, mosquito-prone regions in Africa. In regions where malaria does not occur, individuals who are heterozygous HbA/HbS have a fitness advantage over those who are homozygous for the normal hemoglobin allele (HbA).
Genetic Variation
Genetic variation refers to the variation in the genome sequences between individual organisms of a species. Individual differences or population differences can both be referred to as genetic variations. It is primarily caused by mutation, but other factors such as genetic drift and sexual reproduction also play a major role.
Quantitative Genetics
Quantitative genetics is the part of genetics that deals with the continuous trait, where the expression of various genes influences the phenotypes. Thus genes are expressed together to produce a trait with continuous variability. This is unlike the classical traits or qualitative traits, where each trait is controlled by the expression of a single or very few genes to produce a discontinuous variation.
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