Question 1. Consider the reaction sequence below: OH O HO HO Ph (i) PhMgBr (ii) H+ (a) The reaction needs a protection step. Why? Give the detrimental reaction(s) that will occur if no protection is present. (b) Give the full reaction for the sequence above, including the protection and deprotection steps. Ensure you show all necessary reagents, and catalysts if required:

Question 1. Consider the reaction sequence below: OH O HO HO Ph (i) PhMgBr (ii) H+ (a) The reaction needs a protection step. Why? Give the detrimental reaction(s) that will occur if no protection is present. (b) Give the full reaction for the sequence above, including the protection and deprotection steps. Ensure you show all necessary reagents, and catalysts if required:

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter10: Alcohols

Section: Chapter Questions

Problem 10.50P

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