Answered: Reimer-Tiemann reaction

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Chemistry

Reimer-Tiemann reaction

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter8: Haloalkanes, Halogenation, And Radical Reactions

Section: Chapter Questions

Problem 8.32P

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drug synthesis from Reimer-Tiemann reaction

Expert Solution

Step 1

The ortho-formylation of phenol is carried out by Reimer-Tiemann reaction. The reaction of phenol with chloroform in strong basic conditions gives salicyaldehyde as per the following scheme:

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