10.Answer ALL parts of this question.Prostaglandin-endoperoxide synthase 2, also known as cyclooxygenase-2 or COX-2, is an enzyme that in humans is encoded by the PTGS2 gene.(a) Explain how this enzyme facilitates prostaglandin biosynthesis byhighlighting two key functions.(b) Describe one role for the COX-1 enzyme.(c) Name one condition that the selective COX-2 inhibitors Vioxx (Rofecoxib)and Celebrex (Celecoxib) were used to treat.(d) Name and draw the chemical structures of 4 other small molecule OCOX-2inhibitors and identify 3 similarities/common features with respect toRofecoxib and Celecoxib.(e) Name a therapeutic reason for targeting COX-3.Describe the function and therapeutic utility of non-steroidal anti-(f)inflammatory drugs.

Prostaglandins directly act upon nerve endings to induce pain. They may also speed up the process of…

rostaglandin-endoperoxide synthase 2, also known as cyclooxygenase- or COX-2, is an enzyme that in humans is encoded by the PTGS2 gene. a) Explain how this enzyme facilitates prostaglandin biosynthesis by highlighting two key functions. b) Describe one role for the COX-1 enzyme. c) Name one condition that the selective COX-2 inhibitors Vioxx (Rofecoxib)

rostaglandin-endoperoxide synthase 2, also known as cyclooxygenase- or COX-2, is an enzyme that in humans is encoded by the PTGS2 gene. a) Explain how this enzyme facilitates prostaglandin biosynthesis by highlighting two key functions. b) Describe one role for the COX-1 enzyme. c) Name one condition that the selective COX-2 inhibitors Vioxx (Rofecoxib)

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter4: Cells

Section: Chapter Questions

Problem 1ITD

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