Select whether the property is likely to increase, decrease, or would have noeffect in the given parameter. *IncreaseDecreaseNo effectLow Ka : Dissolutionrate in aqueoussolventHigh pH : Excretionrate in alkaline urineParticle sizereductionDissolution rateLow particle surfacearea : DissolutionrateLipophilicityAbsorption acrossBBBHigh partitioncoefficient :BioavailabilityAmorphouspolymorphDissolution rateDrug-receptor ionicinteractions : Affinityto receptorsConformationalflexibility : ReceptorselectivityCovalent bondingDuration of actionO O

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Select whether the property is likely to increase, decrease, or would have no effect in the given parameter." Increase Decrease No effect Low Ka : Dissolution rate in aqueous solvent High pH : Excretion rate in alkaline urine Particle size reduction: Dissolution rate

Select whether the property is likely to increase, decrease, or would have no effect in the given parameter." Increase Decrease No effect Low Ka : Dissolution rate in aqueous solvent High pH : Excretion rate in alkaline urine Particle size reduction: Dissolution rate

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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