Select whether the property is likely to increase, decrease, or would have no effect in the given parameter.* Increase Decrease No effect Low Ka: Dissolution rate in aqueous solvent High pH : Excretion rate in alkaline urine Particle size reduction: Dissolution rate Low particle surface area: Dissolution rate Lipophilicity: Absorption across BBB High partition coefficient: Bioavailability Amorphous polymorph : Dissolution rate Drug-receptor ionic interactions :Affinity to receptors Conformational flexibility: Receptor selectivity Covalent bonding :Duration of action

Select whether the property is likely to increase, decrease, or would have no effect in the given parameter.* Increase Decrease No effect Low Ka: Dissolution rate in aqueous solvent High pH : Excretion rate in alkaline urine Particle size reduction: Dissolution rate Low particle surface area: Dissolution rate Lipophilicity: Absorption across BBB High partition coefficient: Bioavailability Amorphous polymorph : Dissolution rate Drug-receptor ionic interactions :Affinity to receptors Conformational flexibility: Receptor selectivity Covalent bonding :Duration of action

Principles of Instrumental Analysis

7th Edition

ISBN:9781305577213

Author:Douglas A. Skoog, F. James Holler, Stanley R. Crouch

Publisher:Douglas A. Skoog, F. James Holler, Stanley R. Crouch

Chapter34: Particle Size Determination

Section: Chapter Questions

Problem 34.10QAP

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