Step 2: A Grignard reagent is strongly basic. The Grignard reagent acts as a source of R anions, which can act as both a bas and a nucleophile. The reaction must be performed in anhydrous conditions, as the presence of water will quench all the Grignard reagents. (RMgBr + H₂O → RH + HOMgBr) What other functional groups will be incompatible with a Grignard reagent? Select the Grignard reagents that contain incompatible functional groups. H₂C=CHCH₂MgBr O= MgBr HOCH₂ CH₂ MgBr HOOC–CH,CH,MgBr CH₂ CH₂ CH₂ MgBr

Organic Chemistry: A Guided Inquiry
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Author:Andrei Straumanis
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Chapter16: Synthesis Workshop 1
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Step 2: A Grignard reagent is strongly basic. The Grignard reagent acts as a source of R¯ anions, which can act as both a base
and a nucleophile. The reaction must be performed in anhydrous conditions, as the presence of water will quench all the
Grignard reagents. (RMgBr + H₂O RH + HOMgBr)
What other functional groups will be incompatible with a Grignard reagent?
Select the Grignard reagents that contain incompatible functional groups.
H₂C=CHCH₂ MgBr
MgBr
MgBr
HOCH₂ CH₂ MgBr
HOOC–CH,CH,MgBr
CH₂ CH₂ CH₂ MgBr
Transcribed Image Text:Step 2: A Grignard reagent is strongly basic. The Grignard reagent acts as a source of R¯ anions, which can act as both a base and a nucleophile. The reaction must be performed in anhydrous conditions, as the presence of water will quench all the Grignard reagents. (RMgBr + H₂O RH + HOMgBr) What other functional groups will be incompatible with a Grignard reagent? Select the Grignard reagents that contain incompatible functional groups. H₂C=CHCH₂ MgBr MgBr MgBr HOCH₂ CH₂ MgBr HOOC–CH,CH,MgBr CH₂ CH₂ CH₂ MgBr
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