Suggest a synthesis of (±)-8 from indanone 6 and aldehyde 7. Your answer should include relevant mechanistic detail and may require more than one step. steps ಕ MeO MeO OHC 7 MeO MeO (+)-8
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- Show the complete and detailed reaction mechanism (Curtius Rearrangement) of carboxylic acid 4 that resulted in the formation of isocyanate 5, which, upon electrocyclization furnished pyrrolo[2,3-c]quinoline 6. Intermediate 6 was subsequently transformed into triflate 7, and the total syntheses of marinoquinolines 3a, 3b, and 3e were accomplished by intro- ducing different substituents at the C4 position. (show movement of electrons, charges, arrows, reagents, conditions, biproducts etc. and provide short explanation)Electrophilic nitration of benzoic acid gives almost exclusively 3-nitrobenzoic acid. By drawing the appropriate resonance forms of the intermediate cations resulting from attack of [NO2]+, explain this result.1..Suggest mechanisms for the following reactions:
- Please describe the difference in the outcome of treating a terminal alkyne with HgSO4, H2SO4, H2O and with 9-BBN, followed by H2O2 and NaOH.Following is a synthesis for toremifene, a nonsteroidal estrogen antagonist whose structure is closely related to that of tamoxifen. (a) This synthesis makes use of two blocking groups, the benzyl (Bn) group and the tetrahydropyranyl (THP) group. Draw a structural formula of each group and describe the experimental conditions under which it is attached and removed. (b) Discuss the chemical logic behind the use of each blocking group in this synthesis. (c) Propose a mechanism for the conversion of D to E. (d) Propose a mechanism for the conversion of F to toremifene. (e) Is toremifene chiral? If so, which of the possible stereoisomers are formed in this synthesis?8. The preparation of the sex pheromone of the boll worm moth, (E)-9,11-dodecadien-1-yp acetate from compound A has been described. Suggest suitable reagents for each step in sequence.
- When a mixture of ketone 11 and \alpha, \beta - unsaturated carbonyl 12 are exposed to substoichiometric amounts of NaOMe, product B is obtained selectively. Subsequent treatment of B with excess NaOMe leads to the exclusive formation of tricyclic product 13. (1) Suggest a structure for B and provide a reason for its selective formation. (ii) Provide a reaction mechanism for the formation of 13, which accounts for its selective formation.I need help to find the mechansim for Preparation of Cyclohexanone by Na2CrO3/H2SO4 and explain the mechanisms step by step so I can understand it pleaseWhen 2,2-dibromo-1-phenylpropane is heated overnight with sodium amide at 150 °C, the major product (after addition of water) is a different foul-smelling compound of formula C9H8. Propose a structure for this product, and give a mechanism to account for its formation.
- Propose a mechanism for the reaction of aniline with ethyl acetate to give acetanilide.What is the leaving group in your proposed mechanism? Would this be a suitableleaving group for an SN2 reaction?9. Product of the reaction of nitrobenzene with sulfuric acid in the presence of oleum at 60 °C:a) o-nitro benzenesulfonic acidb) m-nitro benzenesulfonic acidc) p-nitro benzenesulfonic acidd) None of the above 10. Due to their ability to move through ducts or pipes, they are generally called fluids:a) Solidsb) Solid mixturesc) Gasesd) Liquids and gasesReaction of Aldehydes and Ketones with Organometallics: Grignard and Lithium For the following reactions: 1) Illustrate the reaction for the formation of the organometallic 2) Write the product of the reaction 3) Illustrate the mechanism of the reaction with arrow movement.