Suppose that a G protein undergoes a mutation that allows the exchange of bound GTP for GDP to occur in the absence of G protein binding to a re- ceptor. How might this mutation affect signaling involving a GPCR? Which subunit of the G protein is most likely affected by the mutation?

Suppose that a G protein undergoes a mutation that allows the exchange of bound GTP for GDP to occur in the absence of G protein binding to a re- ceptor. How might this mutation affect signaling involving a GPCR? Which subunit of the G protein is most likely affected by the mutation?

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter4: Principles Of Neural And Hormonal Communication

Section: Chapter Questions

Problem 5RE: Second-messenger systems ultimately bring about the desired cell response by inducing a change in...

See similar textbooks

Related questions

Q: What are the three steps by which receptor tyrosine kinases typically convey an extracellular signal…

A: Answer : The three steps involved are :- Step1) Ligand Reduction : The receptors present in the…

Q: Put the following steps for the outline of the growth factor signaling pathway in order: Map Kinase…

A: Activities with constant changes in the environment. In doing so, organisms use a number of pathways…

Q: Describe three different responses of a cell-surfacereceptor on binding a signaling molecule and…

A: Cell surface receptors also called transmembrane receptors are present on the plasma membrane of the…

Q: Discuss Signaling by Receptors that Interact with Cytoplasmic Janus Kinases?

A: Receptors are the surface proteins found on the plasma membrane of a cell. Receptors bind with the…

Q: Which of the following is not a characteristic of a G protein-coupled receptor? O A. Can recognize a…

A: Cell signaling is crucial for many physiological processes. It involves the binding of the ligand to…

Q: If you could design a drug to overcome the affect of the newly evolved Listeria protein to restore…

A: Listeria proteins are secreted by the bacteria Listeria monocytogenes which is Gram-positive…

Q: Draw the general structural features of a G-protein coupled receptor (GPCR)

A: G-protein coupled receptor (GPCR) are one of the most largest and diverse group of receptors found…

Q: If a cell expresses a dominant-negative tyrosine-kinase-linked receptor (RTK) that lacks the kinase…

A: Receptor tyrosine kinases (RTKs) are enzyme-linked receptors localized at the plasma membrane…

Q: Explain how G Protein Coupled receptors activate G proteins and how RGS (Regulator of G Protein…

A: The explanation for the above question is given below.

Q: In a cat, guanylyl cyclase (which receptor that receives the first messenger and initiates the cell…

A: Guanylyl cyclase is an enzyme that catalyzes the conversion of GTP (guanosine monophosphate) to cGMP…

Q: At which of the following steps in a signaling pathway can amplification of the signal occur? Select…

A: The transfer of chemical signals from the exterior to an interior of a cell is known as signal…

Q: Given the existence of leak channels for both K and Na , could the membrane repolarize C688 if the…

A: Ion use transport protein known as gated or leak channels to enter the cell. It is known as…

Q: Paracrine signaling is characterized by ligands that are __________. produced by the cell itself…

A: The process by which a cell receives or sends signals within itself and with the other cells is…

Q: Identify molecule (1) in the pathway of hormonal regulation illustrated below: (A) ion channel (B)…

A: In the given image, we are shown signal transduction pathway in which a hormone is binding to a…

Q: cholerae, disrupt G Protein Coupled Receptor (GPCR) signaling pathways. They interfere with... the…

A: GPCR is a family of cell surface receptors that perform its action mainly through the action of GTP…

Q: What is the benefit of using second messengers and phosphorylation cascades during the transduction…

A: Cell signaling involves the transmission of a signal from a sending cell to a receiving cell. Cells…

Q: Arrange signalling cascade events in chronological order.…

A: Signaling pathways helps to respond the cells according to the external stimuli. The external…

Q: Is protein kinase A a second messenger in the adenylate cyclase pathway?

A: Secondary messenger is the low molecular weight, intracellular molecule produced in high…

Q: What are G-protein-coupled receptors? Explain their function in regard to how particular…

A: Cell surface receptors are the proteins embedded in the membrane. These are integral membrane…

Q: reate a diagram which illustrates the typical signaling mechanism of action of g protein coupled…

A: Cell Signaling -- Cell signaling is a process or communication ability of a cell to receive ,…

Q: Binding of a ligand (like TGFA) to a receptor tyrosine kinase (RTK) causes all of the following…

A: Tyrosine kinase are cell surface proteins They are very active throughout the life of a cell and…

Q: Describe three ways in which a gradual increase inan extracellular signal can be sharpened by the…

A: Extra cellular signalling is considered an important aspect of a living organism. It plays a…

Q: When a G-coupled receptor is activated, does the By subunit activate any pathways? If yes, describe…

A: G-protein-coupled receptors(GPCRs) are the largest family of cell-surface receptors. The…

Q: To examine: Whether the statement "most intracellular signaling pathways provide numerous…

A: Cell signalling, also known as cell-cell communication, is responsible for directing the basic…

Q: Give an example of contact-dependent signaling. What are some proteins involved?

A: Cell to cell interaction is very much important during the developmental process and it involves…

Q: What is cGMP-dependent protein kinase?

A: A chemical process or chemical reaction is the formation of new substances ( product) from reactant…

Q: What is the difference between a G protein and a receptor tyrosine kinase? Give an example of a…

A: Proteins are synthesized from the polypeptide molecules and function in several metabolic roles.

Q: Most mammalian cells have a single immobile cilium called the primary cilium, in which…

A: Intraflagellar transport (IFT) is the process by which proteins are transported into cilia. It…

Q: Binding of a signaling molecule to which typeof receptor leads directly to a change in…

A: The cells in the multicellular organisms communicate through the signaling molecules that are…

Q: What role, if any, do the noncanonical Wnt signaling pathways have inplanarian regeneration?

A: Regeneration is an evolutionarily conserved process in animal kingdoms, however, the regenerative…

Q: Arrange signalling cascade events in chronological order. Release of Ca2* ions triggered by IP3…

A: A signaling cascade also known as a signaling pathway is a series of reactions that occur within a…

Q: Explain , What role does phosphorylation of tyrosine residues play in the action of receptor…

A: the phosphorylation of thyrosine residues play an important role in the action of receptor proteins…

Q: What do the cytoplasmic domain of a G protein-coupled receptor and the adaptor protein in the RTK…

A: Cells communicate each other by a process known as cell signaling. A ligand molecule binds with the…

Q: Describe the process and results of receptor-ligand binding

A: Ligand can be defined as a substance that binds with another molecule to form a complex structure.…

Q: Which of the following steps amplify the epinephrine signal response in cells: receptor activation…

A: Protein kinase A (PKA) is a well-known kinase that is involved in a wide range of biological…

Q: Jhat are the two problems that a protein component of an intracellular signaling circuit must solve?

A: Intracellular target enzymes are triggered by cell surface receptors. Such enzymes are coupled with…

Q: Explain how FRET could be used to monitor the association of Gαs and adenylyl cyclase following…

A: How does fret, a sort of fluorescence can be utilised to essentially check Its interaction of the…

Q: If a cell wants to directly affect transcription of genes by utilizing cell signaling which of the…

A: Signalling molecules or ligands are those which carries the specific information. Signalling…

Q: Choose the signaling or type of receptor for each

A: Dear student. Answer:- 1)This is an inhibitory type of receptor mainly found in CNS.GABA(gamma…

Q: Describe how you would experimentally demonstrate that a specific G beta protein subunit is required…

A: Cells communicate with each other via released proteins unique to each kind. Signal transduction…

Q: Briefly explain in your words the role of how Inside-out signaling of integrin occurs?

A: Integrin is a large family of transmembrane receptors for extracellular matrix and cell-surface…

Q: Compare and contrast signaling via G-protein coupled receptor, receptor tyrosine kinases, nuclear…

A: The comparison between G-protein coupled receptor, receptor tyrosine kinases, nuclear receptor with…

Q: To move in a specific direction, a migrating cell must use extracellular cues to establish which…

A: Introduction GTPases are a wide family of hydrolase enzymes that attach to and hydrolyze the…

Q: When a signal ligand binds to the extracellular portion of the RTK receptor, in the MAP kinase…

A: A receptor is a protein which binds to a specific molecule. The molecule it binds is known as the…

Q: What is a key characteristics of a G protein-linked receptors? a. it allows ions to flow through…

A: GPCR (G Protein-Coupled Receptores) is the cell surface receptor that transmits a signal into the…

Q: What common features are shared by most cell signaling systems?

A: The key membrane-bound unit that contains the basic molecules of life and is composed of which all…

Q: Once an activated signaling pathway has elicited the proper changes in target gene expression, the…

A: In biological systems, the type of regulation in which the final product results in the decline of…

Q: What are the sequences of events by which the binding of a chemical messenger to a receptor causes…

A: A chemical messenger is any substance that is used to deliver a message and can include: Hormone is…

Question

Suppose that a G protein undergoes a mutation that allows the exchange of
bound GTP for GDP to occur in the absence of G protein binding to a re-
ceptor. How might this mutation affect signaling involving a GPCR? Which
subunit of the G protein is most likely affected by the mutation?

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

This is a popular solution!

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Trending now

This is a popular solution!

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Similar questions

How is an extracellular signal converted to an intracellular signal in signal transduction? Give a specific example.
Second-messenger systems ultimately bring about the desired cell response by inducing a change in the shape and function of particular designated intracellular proteins. (True or false?)
Suppose that a G protein undergoes a mutation that allows the exchange of bound GTP for GDP to occur in the absence of G protein binding to a receptor. How might this mutation affect signaling involving a GPCR? Which subunit of the G protein is most likely affected by the mutation?
Which components of the phosphoinositide signaling system are soluble and which are associated with the membrane?
Can you please describe the role of G proteins in ligand-activated cellular signal transduction.
Describe three different responses of a cell-surfacereceptor on binding a signaling molecule and undergoing aconformational change.
Briefly explain how integrin inside-out and outside-in signaling is different structurally and functionally? (hint: explain what happened to ligand binding and conformation)
Explain how an indirect neurotransmitter receptor mechanism (like A-G linked receptor) conduct cell signaling?
To move in a specific direction, a migrating cell must use extracellular cues to establish which portion of the cell will act as the front and which will act as the back. Describe how small GTPase proteins appear to be involved in the signaling pathways used by migrating cells to determine direction of movement.
Explain how G Protein Coupled receptors activate G proteins and how RGS (Regulator of G Protein Signaling) inactivate G proteins.
Activation of certain GPCRs triggers an intracellular signaling mechanism that involves activation of adenlyl cyclase and an increase of cAMP. Which of the following statements best describes the the events that follow such a cAMP increase? a.) The cAMP increase leads to activation of protein kinase C. b.) The cAMP increase leads to activation of the release of the gamma subunit from the GPCR. c.) The cAMP increase leads to activation of protein kinase A.
What triggers the activation of G proteins? When triggered, what do G proteins do? Explain how a signal transduction process within a cell may be inactivated.