Suppose we have a cell with a resting membrane potential of -70 mV. The Na+ concentrations in the ECF and ICF are as follows: [Na+]ECF = 50 mM and [Na+]ICF = 50 mM. (a) Which direction (into or out of the cell) will Na+ flow if acted on only by its concentration force? Which direction will Na+ flow if acted on only by its electrical force? (b) Under these conditions, what is the equilibrium potential for Na+? (c) If we increase permeability to Na+ (by opening up a pathway in the membrane,) where will Na+ move and why? (d) How will this change Vm? Is this depolarization or hyperpolarization? (e) Please draw a figure of Vm as a function of time in this scenario
Suppose we have a cell with a resting membrane potential of -70 mV. The Na+ concentrations in the ECF and ICF are as follows: [Na+]ECF = 50 mM and [Na+]ICF = 50 mM. (a) Which direction (into or out of the cell) will Na+ flow if acted on only by its concentration force? Which direction will Na+ flow if acted on only by its electrical force? (b) Under these conditions, what is the equilibrium potential for Na+? (c) If we increase permeability to Na+ (by opening up a pathway in the membrane,) where will Na+ move and why? (d) How will this change Vm? Is this depolarization or hyperpolarization? (e) Please draw a figure of Vm as a function of time in this scenario
Chapter21: Potentiometry
Section: Chapter Questions
Problem 21.11QAP
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Suppose we have a cell with a resting membrane potential of -70 mV. The Na+ concentrations in the ECF and ICF are as follows: [Na+]ECF = 50 mM and [Na+]ICF = 50 mM. (a) Which direction (into or out of the cell) will Na+ flow if acted on only by its concentration force? Which direction will Na+ flow if acted on only by its electrical force? (b) Under these conditions, what is the equilibrium potential for Na+? (c) If we increase permeability to Na+ (by opening up a pathway in the membrane,) where will Na+ move and why? (d) How will this change Vm? Is this depolarization or hyperpolarization? (e) Please draw a figure of Vm as a function of time in this scenario
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