The acidity of the stomach is maintained by the H*/K* ATPase in parietal cells of the gastric mucosa.These cells have an internal pH = 7.4. The H*/K* ATPase transports H* across the cellular membrane into thestomach where pH = 0.8.(a) Given a membrane potential of 65 mV (inside negative), calculate AG in kJ/mol for the transport of H* into thestomach at 37 °C. Show your work.(b) The hydrolysis of ATP is directly coupled to H* transport and the stoichiometry of the transport reaction is suchthat 1 mol of ATP is hydrolyzed for every 1 mol of H* transported into the stomach. ATP is hydrolyzed by theATPase on the inside of the cell. Under the conditions given in part (a) and assuming the steady-stateconcentrations of ATP, ADP and P₁ given below, is the transport of H* in to the stomach thermodynamicallyfavorable at 37 °C? Show the calculation that supports your answer.Steady-state intracellular concentrations:ATP = 4.2 mMADP = 360 μMPi = 5.4 mMFor ATP hydrolysis at 37 °C: ATP + H₂O → ADP + Pi + H+AG" = -32.2 kJ/mol.

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Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter11: The Blood

Section: Chapter Questions

Problem 1SQE

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