Follow these directions to access the entries for PTGS1 and PTGS2 in the “Gene” database at theNCBI Website:A. First, go to the NCBI homepage using the link on the lab webpage, or by going to:http://www.ncbi.nlm.nih.govSelect “Gene” from the database pulldown menu. Type “PTGS” in the search box, thenclick “Go.”Scan the results for the “Homo sapiens” entries. There should be one called “PTGS1” andone called “PTGS2.”Select each entry by clicking on its name, then read the paragraph under the “Summary”section for each entry.The drug Celebrex selectively inhibits PTGS2 while aspirin and other NSAID’s inhibitboth PTGS1 and PTGS2 in the same way. Why do you think researchers wanted todiscover a selective inhibitor to PTGS2? 2. Describe how studying 3-D structures of PTGS1 and PTGS2 could help researchersdesign a drug that binds to PTGS1, but not to PTGS2.

Prostaglandin- endoperoxide synthase (PTGS) is also called as cyclooxygenase which helps in…

The drug Celebrex selectively inhibits PTGS2 while aspirin and other NSAID’s inhibit both PTGS1 and PTGS2 in the same way. Why do you think researchers wanted to discover a selective inhibitor to PTGS2? 2. Describe how studying 3-D structures of PTGS1 and PTGS2 could help researchers design a drug that binds to PTGS1, but not to PTGS2.

The drug Celebrex selectively inhibits PTGS2 while aspirin and other NSAID’s inhibit both PTGS1 and PTGS2 in the same way. Why do you think researchers wanted to discover a selective inhibitor to PTGS2? 2. Describe how studying 3-D structures of PTGS1 and PTGS2 could help researchers design a drug that binds to PTGS1, but not to PTGS2.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter15: Genomes And Genomics

Section: Chapter Questions

Problem 9QP

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