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- Outline the molecular mechanism for skeletal muscle contraction. At what point is ATP used and why?Define the all-or-none principle. The same student remarked that at 180 mV stimulus, it is expected that 100 g mass is lifted by the muscle fibre. Do you agree or disagree? Why or why not?Explain the intracellular mechansim of smooth muscle relaxation of agaonist such as mepyrimine and atropine. Give diagram for each.
- Summation in a single muscle fibre means that Select one: a. the fibre increases the frequency of contraction b. the fibre stays contracted longer c. the fibre increases the force of the contraction and stays contracted longer d. the fibre increases the force of the contraction e. the fibre increases both the force and frequency of contractionExplain the intracellular mechansim of smooth muscle relaxation of agaonist such as mepyrimine and atropine.Provide a explantion and diagram of the Intracellular mechanism of smooth muscle relaxation via antagonists such as atropine binding and blocking muscarinic receptors M3. explain how Atropine blocks the acetylcholine receptors
- Explain how the process of skeletal muscle excitation–contraction coupling demonstrates the general principle of physiology that controlled exchange of materials occurs between compartments and across cellular membranes.The 2 main proteins in muscle cells are _______ and ___The single-fiber twitch experiments shown here were generated by stimulating the muscle cell membranes to threshold with an electrode and measuring the resulting action potential and force. How would the results differ if Ca21 were removed from the extracellular solution just before the electrical stimulus was applied?
- In human resting muscle cells, the concentration of ATP is 4 mM, ADP is 0.013 mM, creatine-phosphate is 25 mM and creatine is 13 mM. Calculate the ΔG for the formation of creatine phosphate from ATP and creatine in kJ/mol and do not include unit in your answer.a. Define threshold potential. b. One student commented that the threshold potential for this muscle fibre is exactly 50 mV. Do you agree or disagree? Why or why not?Distinguish between skeletal, smooth, and cardiac muscle in terms of location and whether they have sarcomeres. Use the sliding filament model to draw how thin filaments, thick filaments, and Z lines move during muscle contraction. Predict how perturbations of acetylcholine release, reception, or breakdown will influence muscle contraction. Predict how perturbations of actin, troponin, tropomyosin, myosin, or calcium would influence muscle contraction. Distinguish between the sympathetic and parasympathetic nervous system. Predict how changes in stress levels or situations would affect activation of the sympathetic and parasympathetic nervous system, levels of epinephrine and norepinephrine, and blood pressure.