The first step in the mechanism for the reaction of an amine with a carboxylic acid to produce an amide is: A) N2 loss B) an acid-base reaction C) loss of C02 D) a nucleophilic attack on the carbonyl carbon E) loss of H20

The first step in the mechanism for the reaction of an amine with a carboxylic acid to produce an amide is: A) N2 loss B) an acid-base reaction C) loss of C02 D) a nucleophilic attack on the carbonyl carbon E) loss of H20

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions

Section21.SE: Something Extra

Problem 30VC

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Question

The first step in the mechanism for the reaction
of an amine with a carboxylic acid to produce an
amide is:
A) N2 loss
B) an acid-base reaction
C) loss of C02
D) a nucleophilic attack on the carbonyl carbon
E) loss of H20

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