The goal of most gene therapies is to insert a healthy copy of a gene into the genome. Besides CRISPR, techniques for integrating DNA into the genome do not target that DNA to a particular genomic location and thus different cells end up with the DNA sequence in different positions. B. The same gene integrated into different locations in the genome will be expressed differently. Why?

The goal of most gene therapies is to insert a healthy copy of a gene into the genome. Besides CRISPR, techniques for integrating DNA into the genome do not target that DNA to a particular genomic location and thus different cells end up with the DNA sequence in different positions. B. The same gene integrated into different locations in the genome will be expressed differently. Why?

Concepts of Biology

1st Edition

ISBN:9781938168116

Author:Samantha Fowler, Rebecca Roush, James Wise

Publisher:Samantha Fowler, Rebecca Roush, James Wise

Chapter10: Biotechnology

Section: Chapter Questions

Problem 7RQ: What is the most challenging issue facing genome sequencing? a. the inability to develop fast and...

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The goal of most gene therapies is to insert a healthy copy of a gene into the genome. Besides CRISPR, techniques for integrating DNA into the genome do not target that DNA to a particular genomic location and thus different cells end up with the DNA sequence in different positions. A. It has been shown that where the healthy gene integrates is heavily influenced by chromatin. Why? B. The same gene integrated into different locations in the genome will be expressed differently. Why? C. Over time the expression of an integrated gene will change, usually decreasing. Describe how you think the cell downregulates expression of an integrated gene.
CRISPR techniques allow scientists to modify specific genes while sparing all others, thus clarifying the association between a given gene and its consequence to the organism. If this technology can change the future of Medicine, what specific benefits CRISPR can bring to genetic testing or analysis? How can CRISPR help to enhance gene therapy or treatment of genetic diseases?
A mouse gene was identified and determined to be required for formation of heart muscle. A gene with a similar sequence was identified in the human genome. What experiment could scientists do to determine if the mouse and human genes have similar functions? A. The scientist could place the normal human gene into normal mice and see if the resulting mice are viable. B. The scientist could search the human genome for genes that encode proteins that are identical to the protein encoded by the mouse gene. C. The scientist could place the normal human gene into mutant mice to see if heart muscle forms in the mouse. D. The scientist could place the mutant mouse gene into humans to see if humans develop without heart muscle.
Determination of the entire DNA sequence of an organism is an example of ________ , while determination of the genes that are expressed in a particular cell type is an example of ________. a. genomic;proteomics b.functional genomics; structural genomics c. cloning; mapping d. structural genomics; functional genomics e. functional genomics; proteomics
The overall goal of the ENCODE Project is a. to sequence the entire genome from many different people. b. to identify all of the functional elements in the human genome. c. to study the expression of selected human genes. d. none of the above.
The first attempts at gene therapy began in 1990 with the treatment of a young girl with a genetic disorder abbreviated SCID. What does SCID stand for? In the context of SCID, what does ADA stand for?
Why can’t all genetic diseases be treated with gene therapy ? Explain how the ideal procedure for gene therapy would work ?
A. What are some reasons a person might want to clone a human? B. What animal was cloned in 1885?
CRISPR is a powerful gene editing tool because a. the programmable enzyme (Cas9) can find an exact sequence and make a cut at precise nucleotide. b. it can be applied to all types of cells. c. it has both genetic editing and epigenetic functions. d. it is inexpensive. e. all of these are correct
The CRISPR-Cas9 system can be used to: a. sequence a genome in living cells b. edit a gene in living cells and organisms c. diagnose sickle-cell anemia d. identify a specific gene e. detect gene expression under different conditions
DNA technology has many medical applications. Which of the following is not done routinely at present? (A) production of hormones for treating diabetes and dwarfism (B) analysis of gene expression for more informed cancer treatments (C) gene editing by the CRISPR-Cas9 system in viable human embryos to correct genetic diseases (D) prenatal identification of genetic disease alleles
The purpose of a ChIP-chip assay is to determinea. the expression levels of particular genes in the genome.b. the sites in a genome where a particular protein binds.c. the amount of a specific protein that is made in a given cell type.d. any of the above.