The locations of numerous lacI- and lacIS mutations have been determined within the DNA sequence of the lacI gene. Among these, lacI- mutations were found to occur in the 5=-upstream region of the gene, while lacIS mutations were found to occur farther downstream in the gene. Are the locations of the two types of mutations within the gene consistent with what is known about the function of the repressor that is the product of the lacI gene?

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter10: From Proteins To Phenotypes
Section: Chapter Questions
Problem 21QP: Transcriptional regulators are proteins that bind to promoters (the 5-flanking regions of genes) to...
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The locations of numerous lacI- and lacIS mutations have been
determined within the DNA sequence of the lacI gene. Among
these, lacI- mutations were found to occur in the 5=-upstream
region of the gene, while lacIS mutations were found to occur farther
downstream in the gene. Are the locations of the two types of
mutations within the gene consistent with what is known about
the function of the repressor that is the product of the lacI gene?

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