The NFAT family is a ubiquitous family of transcription factors. a. Under resting conditions, where is NFAT localized in a cell?  b. Under activated conditions, where is NFAT localized in a cell? c. How is it released from its resting condition and permitted to relocalize? d. Immunosuppressant drugs such as cyclosporin act via inhibition of the calcineurin phosphatase. If NFAT is ubiqitous, how do you think these drugs might act with so few side effects on other signaling processes within the body?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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The NFAT family is a ubiquitous family of transcription factors.

a. Under resting conditions, where is NFAT localized in a cell? 

b. Under activated conditions, where is NFAT localized in a cell?

c. How is it released from its resting condition and permitted to relocalize?

d. Immunosuppressant drugs such as cyclosporin act via inhibition of the calcineurin phosphatase. If NFAT is ubiqitous, how do you think these drugs might act with so few side effects on other signaling processes within the body? 

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