The presence of aspartate stabilizes His+ by 35 kJ/mol. K = [His]/[His+]=10 in solution. What is the new pKa when His+ forms a salt bridge with aspartate? What is the new pKa of that aspartic acid residue?

The presence of aspartate stabilizes His+ by 35 kJ/mol. K = [His]/[His+]=10 in solution. What is the new pKa when His+ forms a salt bridge with aspartate? What is the new pKa of that aspartic acid residue?

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter31: Immunochemistry

Section: Chapter Questions

Problem 31.82P

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Question

The presence of aspartate stabilizes His+ by 35 kJ/mol. K = [His]/[His⁺]=10 in solution. What is the new pKa when His+ forms a salt bridge with aspartate? What is the new pKa of that aspartic acid residue?

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