The Robinson annulation is a combination of two carbonyl coupling reactions, the Michael reaction and the intramolecular aldol condensation. The most common partners in the reaction are a nucleophilic donor (such as a cyclic ketone, a β-keto ester, an enamine, or a β-diketone) and an α,β-unsaturated ketone acceptor. The product is a substituted 2-cyclohexenone derivative.Draw the structures of the nucleophilic β-keto ester and the α,β-unsaturated ketone acceptor that were combined in a Robinson annulation to give the following product: Draw the β-keto ester as an ethyl ester, The Robinsoncarbonyl coupling reactions, the Michael reaction andthe intramolecular aldol condensation. The mostcommon partners in the lidonor (such as a cyclic ketone, a β-keto ester, anenamine, or a β-diketone) and an α,β-unsaturated ketoneacceptor. The product is a substituted 2-cyclohexenonederivativeannulation is a combination of tworeaction are a nucleophiDraw the structures of the nucleophilic B-keto ester andthe α,β-unsaturated ketone acceptor that were combinedin a Robinson annulation to give the following productPhPhPhPhCO2EtDraw the B-keto ester as an ethyl ester

Answered: The Robinson carbonyl coupling…

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter19: Enolate Anions And Enamines

Section19.9: Crossed Enolate Reactions Using Lda

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The Robinson annulation is a combination of two carbonyl coupling reactions, the Michael reaction and the intramolecular aldol condensation. The most common partners in the reaction are a nucleophilic donor (such as a cyclic ketone, a β-keto ester, an enamine, or a β-diketone) and an α,β-unsaturated ketone acceptor. The product is a substituted 2-cyclohexenone derivative.

Draw the structures of the nucleophilic β-keto ester and the α,β-unsaturated ketone acceptor that were combined in a Robinson annulation to give the following product:

Draw the β-keto ester as an ethyl ester,

The Robinson
carbonyl coupling reactions, the Michael reaction and
the intramolecular aldol condensation. The most
common partners in the li
donor (such as a cyclic ketone, a β-keto ester, an
enamine, or a β-diketone) and an α,β-unsaturated ketone
acceptor. The product is a substituted 2-cyclohexenone
derivative
annulation is a combination of two
reaction are a nucleophi
Draw the structures of the nucleophilic B-keto ester and
the α,β-unsaturated ketone acceptor that were combined
in a Robinson annulation to give the following product
Ph
Ph
Ph
Ph
CO2Et
Draw the B-keto ester as an ethyl ester

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

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