The side-chain carboxyl groups of aspartic acid and glutamic acid are often protected as benzyl esters. Me,COČNHCHČOCH3 ВОС as amino- protecting group CH, CH, benzyl ester as carboxyl- protecting group C=0 ÓCH,Ph

Introduction to General, Organic and Biochemistry
11th Edition
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Chapter22: Proteins
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Problem 22.32P
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Show how to convert the side-chain carboxyl group to a benzyl ester using benzyl chloride as a source of the benzyl group.

The side-chain carboxyl groups of aspartic acid and glutamic acid are often protected as
benzyl esters.
Me,COČNHCHČOCH3
ВОС as amino-
protecting group
CH,
CH,
benzyl ester as carboxyl-
protecting group
C=0
ÓCH,Ph
Transcribed Image Text:The side-chain carboxyl groups of aspartic acid and glutamic acid are often protected as benzyl esters. Me,COČNHCHČOCH3 ВОС as amino- protecting group CH, CH, benzyl ester as carboxyl- protecting group C=0 ÓCH,Ph
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