The statement "DNA → RNA → Proteins" -> is known as the central dogma depicts the regulation of gene expression describes a series of catalytic reactions is the same in all organisms, as well as viruses and prions O
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- Process of translation *( Choose True if the statement is correct abourt genetic code and False if otherwise ) includes covalent modification of some proteins participation of rRNA transfer RNA is made from messenger RNA tRNA uses information from mRNA to produce amino acid chainsWhy siRNA phenomenon is utilized in cell biology? Because specific gene silencing leads to blocking protein translation Because specific gene silencing leads to blocking mRNA transcription Because specific gene silencing leads to blocking DNA replication All answers are correctoslorGulolaculGACu When does DNA replication occur in the cell cycle? Replicate this strand of DNA: ATTCGC TAG GU Aanine Transcribe the same piece of DNA Stop GU Valine Cystelne Stop Use the chart to create the amino acid sequence. Arginine AC Leucine Sorine C UG Lysine Proline Define gene mutation Asparagine True or False? All mutations are harmful. Define chromosomal mutation. Histidine Threonine
- Which statement(s) describe the function of the protein encoded by KMT2D ? Transcription factor involved in the DNA damage response. A component of haemoglobin. A subunit of - secreatase. An enzyme invovled in nucleotide biosynthesis. An enzyme involved in the breakdown of glycosaminoglycans (GAGS). Involved in fat and muscle cell differentiation A cell surface protein involved in iron absorption.how would alterning patterns of gene expression in prokaryotes would most likely serve an organism's survival? In a single point mutation, when the RNA and amino acid changes it is called ? what is the DNA sequence called?: 3”TTC ATT TAC TTT CGT TCA TAT TGT ACG ACT CGG TTA5”Which of the following statament is NOT TRUE about gene expression? Lüffen birini seçin: O a. Gene expression is the process by which DNA directs the synthesis of proteins O b. During gene expression, the information encoded in genes is used to make specific polypeptide chains or RNA molecules. O c. The expression of genes that code for proteins includes two stages: replication and translation O d. Translation is the synthesis of a polypeptide using the information in the MRNA.
- Mutation #2: • Change the Mutation to RED TACACC TIG GC GACGACT A U GU G G A A C C G C UG CUGA MET -TRP- ASN - ARG- CYS - (STOP) Original DNA Sequence: MRNA Sequence: Amino Acid Sequence: Mutated TAC GÁC CTT GGC GAC GÁC T DNA mRNA Amino Acid Will this mutation have an effect? What kind of mutation is this? Mutation #3: • Change the Mutation to RED TACACCTT G G C G A C GACT AUGUG G A A C C G C U G C U G A MET -TRP- ASN - ARG- CYS - (STOP) Original DNA Sequence: mRNA Sequence: Amino Acid Sequence: Mutated TAC ACC TTA GCG ACG ACT DNA MRNA Amino Acid Will this mutation have an effect? What kind of mutation isProcess of translation *( Choose True if the statement is correct about Process of translation and False if otherwise ) includes covalent modification of some proteins participation of rRNA transfer RNA is made from messenger RNA tRNA uses information from mRNA to produce amino acid chainsIove aIung the HRNA from codon to codon, the appropriate amino acids are brought into place and linked together according to the sequence of codons. Thus, the code in the mRNA is translated into a special sequence of amino acids. The order of the amino acids in the protein, therefore, is specified by the MRNA, which in turn is transcribed from the DNA. Procedures and Observations: During transcription, the DNA double helix unwinds and "unzips. The two strands separate as the hydrogen bonds binding the nitrogen bases break. Then, nucleotides present in the cell line up along one strand of the DNA, the order of the nucleotides determined by the order of the nucleotides in the DNA. As the mRNA forms, uracil (U) nucleotides match with adenine (A) nucleotides; cytosine (C) nucleotides match with guanine (G) nucleotides. Note: RNA contains uracil (U) nucleotides where thymine (T) nucleotides would occur in DNA. The nucleotides in the newly formed mRNA are complementary to the nucleotides of…
- Which of the following DNA regulatory protein “motifs” consists of three a-helices, in a single polypeptide, acting independently of other polypeptides in the regulation of DNA? the leucine zipper the zinc finger the homeodomain all of the above none of the above Which of the following processes regulates the maturation of mRNA from hnRNA (in the control of gene expression in humans and other eukaryotes)? translation of polypeptides self-replication of DNA processing of RNA transcription of RNA self-replication of RNAGene expression can be affected by all of these EXCEPT: - Considering chromosomes -Adding mote ATP -Degrading mRNA -Degrading proteinsAntibiotics and Protein Synthesis Antibiotics are molecules produced by microorganisms as defense mechanisms. The most effective antibiotics work by interfering with essential biochemical or reproductive processes. Many antibiotics block or disrupt one or more stages in protein synthesis. Some of these are mentioned here. Tetracyclines are a family of chemically related compounds used to treat several types of bacterial infections. Tetracyclines interfere with the initiation of translation. The tetracycline molecule attaches to the small ribosomal subunit and prevents binding of the tRNA anticodon during initiation. Both eukaryotic and prokaryotic ribosomes are sensitive to the action of tetracycline, but this antibiotic cannot pass through the plasma membrane of eukaryotic cells. Because tetracycline can enter bacterial cells to inhibit protein synthesis, it will stop bacterial growth, helping the immune system fight the infection. Streptomycin is used in hospitals to treat serious bacterial infections. It binds to the small ribosomal subunit but does not prevent initiation or elongation; however, it does affect the efficiency of protein synthesis. Binding of streptomycin changes the way mRNA codons interact with the tRNA. As a result, incorrect amino acids are incorporated into the growing polypeptide chain, producing nonfunctional proteins. In addition, streptomycin causes the ribosome to randomly fall off the mRNA, preventing the synthesis of complete proteins. Puromycin is not used clinically but has played an important role in studying the mechanism of protein synthesis in the research laboratory. The puromycin molecule is the same size and shape as a tRNA/amino acid complex. When puromycin enters the ribosome, it can be incorporated into a growing polypeptide chain, stopping further synthesis because no peptide bond can be formed between puromycin and an amino acid, causing the shortened polypeptide to fall off the ribosome. Chloramphenicol was one of the first broadspectrum antibiotics introduced. Eukaryotic cells are resistant to its actions, and it was widely used to treat bacterial infections. However, its use is limited to external applications and serious infections. Chloramphenicol destroys cells in the bone marrow, the source of all blood cells. In bacteria, this antibiotic binds to the large ribosomal subunit and inhibits the formation of peptide bonds. Another antibiotic, erythromycin, also binds to the large ribosomal subunit and inhibits the movement of ribosomes along the mRNA. Almost every step of protein synthesis can be inhibited by one antibiotic or another. Work on designing new synthetic antibiotics to fight infections is based on our knowledge of how the nucleotide sequence of mRNA is converted into the amino acid sequence of a protein. Questions Why are antibiotics ineffective in treating the common cold and other virus infections?