The total amount excreted into urine as unchanged drug after an oral tablet (A) of 50 mg was 36.4 mg. After an oral capsule dose (B) of 25 mg the Uo was 20.3 mg. Calculate the relative bioavailability of the tablet A with respect to capsule B. If the absolute bioavailability of the oral capsule is determined to be 0.86 calculate the absolute bioavailability of the tablet dosage form. You are required to list the given data, formula and steps for calculations
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- KCI for injection contains 40 mEq in 20 mL. An order requires 15 mEq, how many mL are needed?To make up a solution of phosphate buffered saline (PBS), you need 10 mM Na2HPO4 (anhydrous) (FW: 141.96 g/mol), 3 M NaCl (FW: 58.44 g/mol), and 5mM KH2PO4 (FW: 136.09 g/mol). How many grams of each will you need to make up 850 mL of PBS?The amount of calcium in physiologic fluids can be determined by a complexometric titration with EDTA. In one such analysis, a 0.100-mL sample of blood serum was made basic by adding 2 drops of NaOH and titrated with 0.001 M EDTA, requiring 0.238 mL to reach the end point. Report the concentration of calcium in the sample as miligrams of Ca per 100 mL. (Ca = 40.078 amu).
- Given the equation of the line, y=150x-8.1221 (cells per mL is in 10^8), what is the CFU per mL of the original suspension if the thousand-fold dilution of that suspension has an absorbance of 0.3 at 600nm? * A. 3.7 x 10^12 B. 3.7 x 10^9 C. 3.7 x 10^1 D. None of these is correctAfter administration of 150 mg drug A in an oral tablet dosageform, the AUC was calculated to be 143.3 mg•hr/L. Afteradministration of 85 mg drug A in an IV injection dosage form,the calculated AUC was 208.6 mg•hr/L. What is the absolutebioavailability of drug A in the oral tablet dosage form? A. 39%B. 56%C. 69%D. 256%The doctor ordered Oxacillin 650mg every 6 hours. The instructions on the 2gm vial states to reconstitute with powder with 11.5ml of sterile water for injection, yielding 220mg/1.5ml. How many ml will you administer? using dimensional analysis and show work
- A concentrated lidocaine solution contains lidocaine 1 g/5 mL. How many milliliters of this injection should be used to prepare a 500 mL IV infusion containing 8 mg/mL of lidocaine in D5W? Do not round.The healthcare provider orders 90 mg of a drug IVPB q6h for a child. If the label on the drug vial reads 15mg/mL, how many milliliters will you withdraw from the vial to add to the volume control chamber? AND if the recommended concentration of the solution for infusion is 10mg/mL, how many more mL of liquid would you add to the volume control chamber (VCC) to achieve the recommended concentration?If 400 mL of a 20% w/v solution were diluted to 2 L, what would be the finalpercentage strength?
- Calculate the following concentration given thisCalculate the dose in Mg: What is the dose of a patient weighing 30 kg, if the dose is 10 mg/kg?In the experiment performed for the determination of cholesterol, the function of the calibration curve obtained using 25-400mg/dL standard cholesterol solutions was determined as y= 0.0009x. If the amount of cholesterol in the serum sample is determined as 3.11 g/L, what is the absorbance value of the sample? A. 0,280 B. 0.028 C. 0.208 D. 0.82