There are different types of helical structures that can be found in proteins (i.e., not only helices). What is common among different types of helices is that the he structure is maintained by intrachain hydrogen bonding between two polypeptide backbone atoms. Oftentimes, at least two intrachain hydrogen bonds need to be formed in order for a helix to start gaining stability. This can be observed from circular dichroism, technique that detects helicity in proteins. Circular dichroism starts detecting helicity in a helical chain only when there are at least two intrachain hydrogen bond formed. If a helical structure is too short such that it only has one intrachain hydrogen bond, the helix is too unstable for the helicity to be accurately detected th circular dichroism. Four different types of helical structures were studied using circular dichroism and the minimum number of residues needed for helicity to become detectable wa determined as summarized in the table below. Minimum number of residues Helical sample needed for helicity to be detected Helix A Helix B 6 Helix C 7 Helix D 8 For Helix A, if a minimum of five residues are needed for circular dichroism to detect helicity, that means that the intrachain hydrogen bond is formed between v [ Select ] residue I and residue I+3 residue I and residue I+4 residue I and residue I+5 residue I and residue I+6 vvnicn atoms are invorvea in forming intrachain hydrogen bonds in order to produce a helical structures? [ Select] do you think correspo to an a helix? [ Select] and [ Select ) >
There are different types of helical structures that can be found in proteins (i.e., not only helices). What is common among different types of helices is that the he structure is maintained by intrachain hydrogen bonding between two polypeptide backbone atoms. Oftentimes, at least two intrachain hydrogen bonds need to be formed in order for a helix to start gaining stability. This can be observed from circular dichroism, technique that detects helicity in proteins. Circular dichroism starts detecting helicity in a helical chain only when there are at least two intrachain hydrogen bond formed. If a helical structure is too short such that it only has one intrachain hydrogen bond, the helix is too unstable for the helicity to be accurately detected th circular dichroism. Four different types of helical structures were studied using circular dichroism and the minimum number of residues needed for helicity to become detectable wa determined as summarized in the table below. Minimum number of residues Helical sample needed for helicity to be detected Helix A Helix B 6 Helix C 7 Helix D 8 For Helix A, if a minimum of five residues are needed for circular dichroism to detect helicity, that means that the intrachain hydrogen bond is formed between v [ Select ] residue I and residue I+3 residue I and residue I+4 residue I and residue I+5 residue I and residue I+6 vvnicn atoms are invorvea in forming intrachain hydrogen bonds in order to produce a helical structures? [ Select] do you think correspo to an a helix? [ Select] and [ Select ) >
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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