Answered: TOH1 protein is typically expressed at…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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TOH1 protein is typically expressed at the same level in kidney and stomach cells and is essential to appropriate function of both organs. TOH disorder is a disorder where no detectable TOH1 protein is present in kidney cells due to a mutation in the promoter leading to no transcription. No other organs are affected in TOH disorder. You used microarray analysis to examine cells from kidney and stomach cells from the same individual with TOH disorder. You labeled the cDNA from the affected kidney cells with red fluorescent nucleotides, and you labeled the cDNA from the unaffected stomach cells with green fluorescent nucleotides. After you mixed the cDNAs and allowed for hybridization, what color would you expect to see for the spot for the TOH1 gene when you analyze the microarray data?

a) Red

b) Green

c) Black

d) Yellow

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