Trihexphenidyl is a muscarinic antagonist. Based on SAR to preserve the activity which one is not correct. OH 00 a. OH group can be changed with hydroxymethyl. b. You can change the cyclohexyl with a phenyl ring c. C1 carbon is interchangeable with O d. You can change N containing piperidine group to cyclopentyl e. OH group increases antagonistic activity

Trihexphenidyl is a muscarinic antagonist. Based on SAR to preserve the activity which one is not correct. OH 00 a. OH group can be changed with hydroxymethyl. b. You can change the cyclohexyl with a phenyl ring c. C1 carbon is interchangeable with O d. You can change N containing piperidine group to cyclopentyl e. OH group increases antagonistic activity

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter21: Lipids

Section: Chapter Questions

Problem 21.34P

See similar textbooks

Similar questions

Single hydrolysis on the following polypeptide 2. Draw the fisher projection of phenylalanine at pH 1, 7 and 12
PRODUCTS. Match the name of the product with the biochemical reaction. Products may be used more than once. Tests may require more than one answer.a. 2,3-butanediol 1.catalase b. ammonia 2.phenylalanine deamination c.fatty acids 3.triglyceride hydrolysis d. indole 4.tryptophan degradation e.molecular oxygen 5.urea hydrolysis f. phenylpyruvic acid 6.Voges-Proskauer test
Why is –NHCH3 an activator during SEAr, but a deactivator during SNAr?
1) This a model for what type of inhibitor? a) Competitive b) Uncompetitive c) Mixed d) Pure noncompetitive e) All of the above f) None of the above
1. Biogenic Amines are inactivated primarily by a. Sulfonation b. Glucoronidation c. Aromatic hydroxylation d. Methylation 2. A drug can exert its pharmacological effect only if it is a. Protein bound b. Protein unbound c. Free drug d. Both B & C e. Both A & C 3. In order for the drug to be ready and available for absorption, it must be release first from its dosage form with the exception of: a. Capsule b. Tablet c. Solution d. Suspension 4. All of the following are true, except a. Solubility increase with decrease particle size b. Solubility increase with increase surface area c. Solubility increase with increase particle size d. Solubility decrease with decrease surface area 5. The rate in which the drug appears in the bloodstream is also known as a. Half-life b. Potency c. Bioavailability d. Area under the curve
why I need acetylate amino group and reduce the activity in this mechanism?
Please don't provide hnadwrritten solutrion .....
1.Which of the following correlations about the analyses of iodine and saponificationnumbers is/are incorrect?a. Alcoholic KOH: dissolve KOH to lipid sampleb. Hanus reagent: react with saturated lipid bondc. Reflux set-up: hasten reactiond. Blank titration: determine total mol of KOH2. A triacylglycerol (Sample X) was subjected to saponification analysis. 1.1 grams of thesample was refluxed with 5% alcoholic KOH and the refluxed solution was titrated with 17.2 mLof 0.44 M HCl titrant. The blank solution was titrated with 25.6 mL of the titrant.i. What is the saponification number of the sample? ii. Which of the following could be the identity of the sample? Show solutions pls a. Tripalmitin (MW: 807.3)b. Trilaurin (MW: 639.8)c. Triolein (MW: 885:4)d. Tristearin (MW: 891.48)
1 What is the difference between a zymogen and a proenzyme?
For the hydrophobic aggregation of two Concanavalin A subunits (below), ∆S = +0.151 kcal mol-1 K-1. Which of the following will increase the amount of aggregation? (Hint: this is a bimolecular association reaction.) a) adding water b) increasing temperature c) both of the above d) neither of the above
1. What is the role of initiator and inhibitor? 2. What are short stops?
Penicillin makes a covalent bond at the transpeptidase active site (which bond is it?) Why is it not hydrolyzed by water? Codein is a prodrug for morphine (methyl ether derivative). What is the mechanism of prodrug activation ? Sulfonamide is an isostere for which functional groups we've encountered?