Two homologous chromosomes in ES cells are depicted below with the portion of your gene of interest that you target with the CRISPR/Cas9 method. Proposed cleavage sites of Cas9 are shown with arrows. The schematic can also be found at this link.
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- this is what i have said about this image so far, what else can be said aswell including the raw count column. " Interpreting the results of an RNA-Seq analysis is pivotal in understanding the underlying genetic mechanisms of diseases such as breast cancer. In this analysis, Figure 1 provides comprehensive data on differentially expressed genes associated with breast cancer. By delving into the provided information, we can gain valuable insights into the molecular landscape of this disease. First focus is on the gene with the highest fold change, EYA4, situated on chromosome 6. With a staggering fold change of 3604.4176, EYA4 exhibits an unprecedented level of overexpression in cancerous cells compared to normal cells. This profound alteration suggests a pivotal role for EYA4 in breast cancer pathogenesis. The log2 fold change of 11.81555 further emphasizes the magnitude of this difference in gene expression. Statistical significance is evident, with an exceptionally low p-value of…. Early in development, most human cells turn off expression of an essential component of telomerase, the enzyme responsible for addition of telomere repeat sequences (5’-TTAGGG) to the ends of chromosomes. Thus, as our cells proliferate their telomeres get shorter and shorter, but are normally not lost over the course of a lifetime. If cells are removed from the body and grown in culture, however they ultimately enter a state of replicative senescence and stop dividing when their telomeres get too short. By contrast, most human tumor cells express active telomerase, allowing them to maintain their telomeres and grow beyond the normal limit imposed by senescence - good for them, bad for us. Anticipating a universal cure for cancer, you set up a company to screen chemical ‘libraries’ for telomerase inhibitors. The company share price takes a dive, however, when a rival group generates a strain of telomerase-knockout mice. These mice breed happily for several generations, but…Assuming that 32 million histone octamers arerequired to package the human genome, how many his-tone molecules must be transported per second pernuclear pore complex in cells whose nuclei contain 3000nuclear pores and are dividing once per day?
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- In this gene order question, would the order be a/b -- kf -- nm since genes with shorter map unit distances are closely linked?WHIM syndrome is a disease of the immunesystem resulting in warts and frequent infections.The disease is caused by a dominant gain-of-functionmutation in a gene on chromosome 2 called CXCR4.A 38-year-old woman suffering with WHIM syndrome her entire life was suddenly and mysteriouslycured. Genome analysis of her blood precursor cells(stem cells) revealed that many of these cells had achromosome 2 that had undergone chromotripsis—arare (and poorly understood) process where a chromosome is “shattered” into small pieces that are subsequently stitched back together in random order, resultingin many deletions and inversions. Explain howchromotripsis of chromosome 2 in a blood stem cellcould have cured the woman of WHIM syndrome.Drosophila females homozygous for loss-of-functionmutations in the gene aubergine are sterile. RNA-Seqexperiments show that in the ovaries of these females,the levels of RNAs for many kinds of transposable elements are more than 10× higher than in wild-type ovaries. The aubergine gene encodes a Piwi-family protein.a. Why do you think these females are sterile?b. Piwi proteins interact with piRNAs that are transcribed from piRNA gene clusters. Given that thelevels of many kinds of TEs are elevated in mutantovaries, what kinds of DNA sequences do youthink are located in these clusters?c. Many investigators think of piRNAs as a kind ofdefensive mechanism that protects organisms fromthe effects of new transposable elements that mightbe introduced into genomes, for example fromother species. Explain