Two phenotypically normal people marry. Unknown to them, they havea common great-grandfather who suffered from a rare disorder (1 in30,000 affected in the general population) that is inherited as an auto-somal recessive trait (dd). Assume that the people marrying into thispedigree are all DD, that there has been no earlier consanguinity, andthat no affected (dd) individuals have occurred. What is the probabilitythat the first child of this couple (a baby girl) will. be affected? Draw thepedigree.

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Introduction X-linked Inheritance Means That The Gene Causing The Trait Or The Disorder Is Located…

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Two phenotypically normal people marry. Unknown to them, they ha a common great-grandfather who suffered from a rare disorder (1 in 30,000 affected in the general population) that is inherited as an autc somal recessive trait (dd). Assume that the people marrying into thi pedigree are all DD, that there has been no earlier consanguinity, an that no affected (dd) individuals have occurred. What is the probabili that the first child of this couple (a baby girl) will be affected? Draw t

Two phenotypically normal people marry. Unknown to them, they ha a common great-grandfather who suffered from a rare disorder (1 in 30,000 affected in the general population) that is inherited as an autc somal recessive trait (dd). Assume that the people marrying into thi pedigree are all DD, that there has been no earlier consanguinity, an that no affected (dd) individuals have occurred. What is the probabili that the first child of this couple (a baby girl) will be affected? Draw t

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter4: Pedigree Analysis In Human Genetics

Section: Chapter Questions

Problem 14QP: Analysis of Autosomal Recessive and Dominant Traits Huntington disease is a rare, fatal disease that...

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A woman with achondroplasia (a dominant form of dwarfism) anda phenotypically unaffected man have seven children, all of whomhave achondroplasia. What is the probability of producing such afamily if this woman is a heterozygote? What is the probabilitythat the woman is a heterozygote if her eighth child does not havethis disorder?
a human disease known as cystic fibrosis is inherited as a recessive trait.Two unaffected individuals have a first child with the disease. What isthe probability that their next two children will not have the disease?
Assuming (i) that the two chromosomes in everyhomologous pair carry different alleles of somegenes, and (ii) that no crossing-over takes place, howmany genetically different offspring could any onehuman couple potentially produce? Which of thesetwo assumptions (i or ii) is more realistic?
Albinism, a condition characterized by a partial or total lack ofskin pigment, is a recessive human trait. If a phenotypically unaffected couple produce an albino child, what is the probability thattheir next child will be albino?
A rare recessive allele inherited in a Mendelian mannercauses the disease cystic fibrosis. A phenotypically normal man whose father had cystic fibrosis marries a phenotypically normal woman from outside the family, andthe couple consider having a child.a. Draw the pedigree as far as described.b. If the frequency in the population of heterozygotesfor cystic fibrosis is 1 in 50, what is the chance that thecouple’s first child will have cystic fibrosis?c. If the first child does have cystic fibrosis, what is theprobability that the second child will be normal?
Galactosemia is a recessive human disease that istreatable by restricting lactose and glucose in the diet.Susan Smithers and her husband are both heterozygous for the galactosemia gene.a. Susan is pregnant with twins. If she hasfraternal (nonidentical) twins, what is theprobability both of the twins will be girls whohave galactosemia?b. If the twins are identical, what is the probabilitythat both will be girls and have galactosemia?For parts (c–g), assume that none of the children isa twin.c. If Susan and her husband have four children, whatis the probability that none of the four will havegalactosemia?d. If the couple has four children, what is the probability that at least one child will have galactosemia?e. If the couple has four children, what is the probability that the first two will have galactosemia andthe second two will not?f. If the couple has three children, what is the probability that two of the children will have galactosemia and one will not, regardless of order?g. If…
a. The ability to taste the chemical phenylthiocarbamideis an autosomal dominant phenotype, and the inabilityto taste it is recessive. If a taster woman with a nontasterfather marries a taster man who in a previous marriagehad a nontaster daughter, what is the probability thattheir first child will be(1) A nontaster girl(2) A taster girl(3) A taster boyb. What is the probability that their first two childrenwill be tasters of either sex?
Huntington disease is a rare dominant condition in humans that results in a slow but inexorable deteriorationof the nervous system. The disease shows what mightbe called age-dependent penetrance, which is to saythat the probability that a person with the Huntingtongenotype will express the phenotype varies with age.Assume that 50% of those inheriting the HD allele willexpress the symptoms by age 40. Susan is a 35-yearold woman whose father has Huntington disease. Shecurrently shows no symptoms. What is the probabilitythat Susan will show symptoms in five years?
. Tay-Sachs disease is a rare human disease in which toxic substances accumulate in nerve cells. The recessiveallele responsible for the disease is inherited in a simpleMendelian manner. For unknown reasons, the allele ismore common in populations of Ashkenazi Jews ofeastern Europe. A woman is planning to marry her firstcousin, but the couple discovers that their sharedgrandfather’s sister died in infancy of Tay-Sachsdisease.a. Draw the relevant parts of the pedigree, and showall the genotypes as completely as possible.b. What is the probability that the cousins’ first childwill have Tay-Sachs disease, assuming that all peoplewho marry into the family are homozygous normal?
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