under theromodynamic base conditions, the below system gives alkylation at the less substituted alpha carbon. This is because HA is constrained so that it possesses no orbital with the carbonyl pi system of the carbonyl, thus the corresponding conjugate base cannot into the carbonyl and is not stabilized, thus HA is not acidic. H Ме H. Mel H. НА НА

under theromodynamic base conditions, the below system gives alkylation at the less substituted alpha carbon. This is because HA is constrained so that it possesses no orbital with the carbonyl pi system of the carbonyl, thus the corresponding conjugate base cannot into the carbonyl and is not stabilized, thus HA is not acidic. H Ме H. Mel H. НА НА

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter13: Substitution

Section: Chapter Questions

Problem 4E

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