VHL is a tumor suppressor because a. it causes cancer cells to become hypoxic b. it inhibits the enzyme proline hydroxylase c. it promotes the degradation of a powerful transcription factor. d. in the absence of VHL, HIF-1 is ubiquitylated by proline hydroxylase 2. NF-1 is a tumor suppressor because A. it inactivates Ras by promoting the hydrolysis of GTP to GDP B. it promotes the methylation of the Ras gene promoter C. it is a phosphatase that dephosphorylates the kinases in the Ras effector pathways D. it inhibits the GEF (guanine exchange factor) that activates Ras please answer both question cause this is my last posting question thank you

VHL is a tumor suppressor because a. it causes cancer cells to become hypoxic b. it inhibits the enzyme proline hydroxylase c. it promotes the degradation of a powerful transcription factor. d. in the absence of VHL, HIF-1 is ubiquitylated by proline hydroxylase 2. NF-1 is a tumor suppressor because A. it inactivates Ras by promoting the hydrolysis of GTP to GDP B. it promotes the methylation of the Ras gene promoter C. it is a phosphatase that dephosphorylates the kinases in the Ras effector pathways D. it inhibits the GEF (guanine exchange factor) that activates Ras please answer both question cause this is my last posting question thank you

Biology (MindTap Course List)

11th Edition

ISBN:9781337392938

Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Chapter17: Developmental Genetics

Section: Chapter Questions

Problem 8TYU: Which of the following statements about cancer is false? (a) oncogenes arise from mutations in...

See similar textbooks

Similar questions

Most forms of cancer involvea. the activation of a single oncogene.b. the inactivation of a single tumor-suppressor gene.c. the activation of multiple oncogenes.d. the activation of multiple oncogenes and the inactivation ofmultiple tumor-suppressor genes.
BAX proteins stimulate apoptosis. Mutations in BAX genes can help developing cancers but not necessarily trigger a tumor. This is because a. mutations in BAX do not contribute to tumorigenesis, but BAX can prevent the formation of a tumor b. mutations in BAX may over-stimulate apoptosis c. mutations in BAX contribute to tumorigenesis only with other inhibitors of apoptosis d. mutations in BAX prevent the formation of tumors
Which of the following factors contributes to angiogenesis as a result of a tumor growth? Select all that apply: a. Increasing tumor's access to oxygen and nutrients b. Increasing tumor's ability for growth, invasion, and metastasis c. Increasing expression of proto-oncogenes for cancer cells d. Increasing expression of tumor-suppressor genes for cancer cells
Which of the following associated with cancer development would you expect to be tumor promoters and not genotoxic carcinogens (select all that apply)? A. Excessive alcohol consumption that kills liver cells B. Bisphenol A which mimics the activity of estrogen C. Chemical in pesticides that binds and activates a transcription factor that cause activation of NFkB D. Chemical in cigarette smoke that forms adduct with DNA E. A viral infection that causes ulcerative coilitis of GI tract
Which of the following statements correctly describes a characteristic of tumor-suppressor gene? a) they are frequently overexpressed in cancerous cells. b) they are cancer-causing genes introduced into cells by viruses. c) they encode proteins that help prevent uncontrolled cell growth. d) they often encode proteins that stimulate the cell cycle.
In a wild-type cell, the function of a protein encoded by a tumor-suppressor gene is to cause a cell to ______. A.) stop dividing B.)extend its telomeres C.) grow toward a new blood vessel D.) respond to a growth factor
Which of the following accurately compares tumor suppressor genes and proto-oncogenes? A. Both tumor suppressor and proto-oncogenes prevent the spread of cancer by targeting and destroying existing cancer cells. B. A person who has both tumor suppressor and proto-oncogenes will always develop cancer. C. Proto-oncogenes code for growth factors, while tumor suppressor genes inhibit cell division of damaged cells. D. When a proto-oncogene mutates, it becomes a tumor suppressor gene.
a. Why would a mutation in BRCA1 be considered a driver mutation? b. Based on what you’ve learned thus far, would ATM be considered a tumor suppressor? Explain your reasoning.
Tumor-suppressor genes promote cancer whena. they are overexpressed.b. they are expressed in the wrong cell type.c. their function is inactivated.d. they are expressed at the wrong stage of development.
Which of the following is true of tumor suppressor genes? Group of answer choices a) If this gene is overactive, it becomes an oncogene b) If one of the alleles is mutated, there is usually little effect. Two inactivating mutations are usually required for loss of function (recessive mutation). c) If one copy is lost, the gene no longer functions (dominant mutation) d) Tumor suppressors genes usually cause mitosis or cell growth e) Tumor suppressor genes decrease apoptosis
Cancer causing genes are called ________. a. transformation genes b. tumor suppressor genes c. oncogenes d. mutated genes
Some cancers have been treated with drugs that demethylate DNA.Explain how these drugs might work. Do you think the cancer-causinggenes that responded to the demethylation are likely to have beenoncogenes or tumor-suppressor genes? Explain your reasoning.

SEE MORE QUESTIONS

Recommended textbooks for you

Biology (MindTap Course List)

Biology

ISBN:

9781337392938

Author:

Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Publisher:

Cengage Learning

Biology (MindTap Course List)

Biology

ISBN:

9781337392938

Author:

Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Publisher:

Cengage Learning

SEE MORE TEXTBOOKS

GET THE APP

About FAQ Academic Integrity Sitemap Document Sitemap

Contact Bartleby Contact Research (Essays)High School Textbooks Literature Guides Concept Explainers by Subject Essay Help Mobile App

GET THE APP

Privacy

Your CA Privacy Rights

Your NV Privacy Rights

About Ads

Manage My Data

bartleby, a Learneo, Inc. business

	a.	it causes cancer cells to become hypoxic
	b.	it inhibits the enzyme proline hydroxylase
	c.	it promotes the degradation of a powerful transcription factor.
	d.	in the absence of VHL, HIF-1 is ubiquitylated by proline hydroxylase

	A.	it inactivates Ras by promoting the hydrolysis of GTP to GDP
	B.	it promotes the methylation of the Ras gene promoter
	C.	it is a phosphatase that dephosphorylates the kinases in the Ras effector pathways
	D.	it inhibits the GEF (guanine exchange factor) that activates Ras