v[(mmol/L)min-'] [S] (mmol/L) No inhibitor Inhibitor A 1.25 1.72 0.98 1.67 2.04 1.17 2.50 2.63 1.47 5.00 3.33 1.96 10.00 4.17 2.38
v[(mmol/L)min-'] [S] (mmol/L) No inhibitor Inhibitor A 1.25 1.72 0.98 1.67 2.04 1.17 2.50 2.63 1.47 5.00 3.33 1.96 10.00 4.17 2.38
Chapter10: Reconstitution Of Powdered Drugs
Section: Chapter Questions
Problem 3.2P
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Question
The steady-state kinetics of an enzyme are studied in the absence and presence of an inhibitor (inhibitor A). The initial rate is given as a function of
substrate concentration in the following table: (a) What kind of inhibition (competitive, uncompetitive, or mixed) is
involved?
(b) Determine Vmax and KM in the absence and presence of inhibitor.
![v[(mmol/L)min-']
[S] (mmol/L)
No inhibitor
Inhibitor A
1.25
1.72
0.98
1.67
2.04
1.17
2.50
2.63
1.47
5.00
3.33
1.96
10.00
4.17
2.38](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F7c92437c-c247-46c1-a29e-d623448ff740%2F530b2c39-d5c2-47e4-80de-794d939c3659%2F4ndbtkl_processed.png&w=3840&q=75)
Transcribed Image Text:v[(mmol/L)min-']
[S] (mmol/L)
No inhibitor
Inhibitor A
1.25
1.72
0.98
1.67
2.04
1.17
2.50
2.63
1.47
5.00
3.33
1.96
10.00
4.17
2.38
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