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A:
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Q: what effect would an increase in glucose typically have on the activity of glycogen synthase
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- Patients with von Gierke’s disease (a glycogen storage disease) lack glucose-6- phosphatase activity. Two prominent symptoms of this disorder are fasting hypoglycemia and lactic acidosis. Can you explain why these symptoms occur?Glucose 6-phosphatase deficiency is a glycogen storage disease referred to as von Gierke disease. Which of the following symptoms would you NOT expect to see in patients with this disease? (A) severe fasting hypoglycemia (B) excess adipose triglyceride storage and low circulating levels of fatty acids (C) hyperammonemia (D) liver enlargement resulting from excess liver glycogen storage (E) lactic acidosis (F) goutGlucose binds to glycogen phosphorylase and competitively inhibits the enzyme. What is the physiological advantage of this?
- Depending on the body’s needs, into what type of compounds is glucose converted in the pentose phosphate pathway?Which of the following biochemical reactions should be classified as endergonic (endothermic)? conversion of glucose into amylopectin conversion of lactose into glucose and galactose conversion of glycogen into glucose conversion of sucrose into glucose and fructose conversion of amylose into glucoseThe typical human adult uses about 160 g of glucose per day, 120 g of which is used by the brain. The available reserve of glucose (~20 g of circulating glucose and ~190 g of glycogen) is adequate to sustain the individual for about one day. After the reserve has been depleted during starvation, how would the body obtain more glucose?
- what effect would an increase in glucose typically have on the activity of glycogen synthaseFor the two conditions below regarding Glycogenolysis, please explain how glucose release would be affected. Would there be an increased, decrease, or no change compared to “normal” conditions? Also explain which enzyme or reaction is affected and why. Condition 1: the debranching enzyme is inhibited Condition 2: free inorganic phosphate is chelatedHigh amount of citrate decreases the activity of fructose 1,6-bisphosphatase. True or False
- you follow a carbohydrate-free diet, certain metabolic problems occur. Describe glucogenesis and the problems that may arise from this prolonged glucogenesis state.How is the usage of fat as an energy source regulated? What would you expect to be the effect ofcaffeine or theophylline on fatty acid mobilization?At the first stage of glycerol metabolism, the remaining stages are the same as _________?