(What does it me Model 1: General structure of an a-amino acid in acidic, neutral, or basic solution. The building blocks of proteins are a-amino acids, small molecules that contain a carboxylic acid and an amino group. The amino group is connected to the carbon next to the carboxyl group, designated the a carbon. There are 20 different amino acids found in proteins, differing only in the side chain ("R group"). R-CH-C- -CH-C NH₂ basic (high pH) acidic (low pH) neutral Amino acids contain both a carboxylic acid (proton donor) and a basic amino group (proton acceptor). The neutral "zwitterionic" form is commonly found in aqueous solutions with a pH near neutrality. The side chain "R" may be one of 20 choices. R-CH-C-OH T NH3 + R-CH-C-0 1 NH3 Critical Thinking Questions: 1. Identify the a-amino group and the carboxyl group in each structure in Model 1. Ensure all team members agree. 2. Circle the correct ionization state of an amino group a. at low pH: -NH₂ or -NH3* b. near neutral pH: -NH₂ or -NH3* c. at high pH: -NH₂ or -NH3* 3. Circle the correct ionization state of a carboxyl group a. at low pH: -COOH or -COO b. near neutral pH: -COOH or -COO™ c. at high pH: -COOH or -COO-

Chemistry: An Atoms First Approach
2nd Edition
ISBN:9781305079243
Author:Steven S. Zumdahl, Susan A. Zumdahl
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Chapter21: Organic And Biological Molecules
Section: Chapter Questions
Problem 145CP
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ChemActivity 46A
CA46A
Overview of Amino Acids and Proteins
(What does it mean for a protein to be denatured?)
Model 1: General structure of an a-amino acid in acidic, neutral, or basic solution.
The building blocks of proteins are a-amino acids, small molecules that contain a
carboxylic acid and an amino group. The amino group is connected to the carbon next to the
proboxyl group, designated the & carbon. There are 20 different amino acids found he
proteins,
only in the side chain ("R group").
O
R-CH-C-OH
NH3 +
basic (high pH)
acidic (low pH)
Amino acids contain both a carboxylic acid (proton donor) and a basic amino group (proton
acceptor). The neutral "zwitterionic" form is commonly found in aqueous solutions with a pH
near neutrality. The side chain "R" may be one of 20 choices.
a. at low pH: -NH₂ or -NH3+
b. near neutral pH: -NH₂ or -NH3*
c. at high pH: -NH₂ or -NH3*
3. Circle the correct ionization state of a carboxyl group
a. at low pH: -COOH or -COO-
b. near neutral pH: -COOH or -COO™
c. at high pH: -COOH or -COO-
R-CH-C-O
-CH-C
NH3*
neutral
Critical Thinking Questions:
1. Identify the a-amino group and the carboxyl group in each structure in Model 1. Ensure
all team members agree.
2. Circle the correct ionization state of an amino group
a. Valine; in the stomach at pH 1.5
НЗС.
CH3
CH
4. Using Model 2 (on the following page) to help you, draw the structure of the indicated
amino acid as it would commonly exist under the given conditions. Charges are
important.
+
NH3
OOC
O
HOOC
c. Glutamate; in the blood plasma at pH 7.4
cooo
CH2
CH2
R-CH-C-0-
T
NH₂
b. Serine; in the small intestine at pH 10
SH
оос-
(+)
246
CHÍNH
CH
CHNH2
Transcribed Image Text:ChemActivity 46A CA46A Overview of Amino Acids and Proteins (What does it mean for a protein to be denatured?) Model 1: General structure of an a-amino acid in acidic, neutral, or basic solution. The building blocks of proteins are a-amino acids, small molecules that contain a carboxylic acid and an amino group. The amino group is connected to the carbon next to the proboxyl group, designated the & carbon. There are 20 different amino acids found he proteins, only in the side chain ("R group"). O R-CH-C-OH NH3 + basic (high pH) acidic (low pH) Amino acids contain both a carboxylic acid (proton donor) and a basic amino group (proton acceptor). The neutral "zwitterionic" form is commonly found in aqueous solutions with a pH near neutrality. The side chain "R" may be one of 20 choices. a. at low pH: -NH₂ or -NH3+ b. near neutral pH: -NH₂ or -NH3* c. at high pH: -NH₂ or -NH3* 3. Circle the correct ionization state of a carboxyl group a. at low pH: -COOH or -COO- b. near neutral pH: -COOH or -COO™ c. at high pH: -COOH or -COO- R-CH-C-O -CH-C NH3* neutral Critical Thinking Questions: 1. Identify the a-amino group and the carboxyl group in each structure in Model 1. Ensure all team members agree. 2. Circle the correct ionization state of an amino group a. Valine; in the stomach at pH 1.5 НЗС. CH3 CH 4. Using Model 2 (on the following page) to help you, draw the structure of the indicated amino acid as it would commonly exist under the given conditions. Charges are important. + NH3 OOC O HOOC c. Glutamate; in the blood plasma at pH 7.4 cooo CH2 CH2 R-CH-C-0- T NH₂ b. Serine; in the small intestine at pH 10 SH оос- (+) 246 CHÍNH CH CHNH2
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