What features of the dynactin complex enable cytoplasmic dynein to transport cargo toward the microtubule (−) end? What effect could inhibition of dynactin interaction with the +TIP EB1 have on spindle orientation?

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter30: Protein Synthesis
Section: Chapter Questions
Problem 15P
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What features of the dynactin complex enable cytoplasmic dynein to transport cargo toward the microtubule (−) end? What effect could inhibition of dynactin interaction with the +TIP EB1 have on spindle orientation?

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