What is the changes in TZDs (specifically pioglitazone) structure that has direct impact in clinical application? with deep explanation please.

EBK A SMALL SCALE APPROACH TO ORGANIC L
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ISBN:9781305446021
Author:Lampman
Publisher:Lampman
Chapter32A: Preparation Of Benzoin By Thiamine Catalysis
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What is the changes in TZDs (specifically pioglitazone) structure that has direct impact in clinical application?

with deep explanation please.  

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