What is the relationship between non-disjunction, changes in chromosome number and miscarriage?  Why does this happen more in females? How does maternal age change the outcome? Why?

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Chapter9: Patterns Of Inheritance
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What is the relationship between non-disjunction, changes in chromosome number and miscarriage?  Why does this happen more in females? How does maternal age change the outcome? Why?

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Chromosome abnormalities are of 2 types viz.

numerical, where an individual has abnormal number of chromosomes.

structural, where the chromosome's structure has been altered in one of several ways.

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