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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 6, Problem 15QP
Textbook Problem
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A woman gives birth to monozygotic twins. One boy has a normal genotype (46, XY), but the other boy has trisomy 13 (47, +13). What events—and in what sequence—led to this situation?

Summary Introduction

To describe: The events and sequence of events where a woman gives birth to monozygotic twins out of which one boy has a normal genotype (46, XY), but the other boy has trisomy 13 (47,113).

Introduction: Trisomy is the genetic abnormality which occurs due to several factors such as failure of reproductive steps or presence of any teratogen. The deletion and duplication of chromosomes are the main reason. In trisomy, the individual has one extra chromosome along with any pair of chromosomes.

Explanation of Solution

Pictorial representation: Fig.1 represents Robertsonian translocation.

Fig.1: Robertsonian translocation

Aneuploidy is having a number of chromosomes that is not a multiple of the haploid set. In humans, there are 46 chromosomes for the haploid set. Thus, trisomy leads to 47 chromosomes in an individual. Aneuploidy is a result of nondisjunction of one or more chromosomes.

In the case of monozygotic twins who are the result of healthy gametes, trisomy may be possible resulting in one healthy individual and another abnormal. It usually happens after the development of healthy zygote in the two embryos in which one goes to normal cell division path, and another faces trisomy...

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