When the researchers instead used tissue from intestinal musclesrather than brains, they found no naloxone binding. What doesthat suggest about opiate receptors in mammalian muscle?
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When the researchers instead used tissue from intestinal muscles
rather than brains, they found no naloxone binding. What does
that suggest about opiate receptors in mammalian muscle?
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- Describe the opioid receptors. What are the endogenous ligands for those receptors? What happens when an opiate agonist activates its receptor?Enkephalin binds best with :-a- delta ‘δ’ opiate receptorsb- muta ‘μ’ opiate receptorsc- kappa ‘κ’ opiate receptorsd- all opiate receptors with equal affinitySuppose that the circulating concentration of hor-mone is 10–10 M and the Kd for binding to its receptor is 10–8M. What fraction of the receptors will have hormone bound?If a meaningful physiological response occurs when 50% ofthe receptors have bound a hormone molecule, how muchwill the concentration of hormone have to rise to elicit aresponse? The fraction of receptors (R) bound to hormone(H) to form a receptor–hormone complex (R–H) is [R–H]/([R] + [R–H]) = [R–H]/[R]TOT = [H]/([H] + Kd).
- Which drug is afull agonist at opioid receptors with analgesics activitiy equivalent to morphine, a linger duration of action and fewer with drawal sign on abrupt discontinuance than morphine?? 1-fentanyl 2-methadone 3- NalbuphineEpinephrine 1) transmits information across the synapse in the brain but is 2) also released by the adrenal glands into the blood supply. Which neurochemical roles is epinephrine playing in these descriptions? A) 1) neurotransmitter and 2) neurohormone B) 1) neuromodulator and 2) neurohormone C) 1) neurohormone and 2) neuromodulator D) 1) neurotransmitter and 2) neuromodulatorname and describe the isoforms of the leptin receptor.
- During exercise, how does sympathetic nervous systemactivity regulate blood glucose levels? Name fivehormones that interact to ensure that the brain and themuscles have adequate energy sources during exercise,and explain the role of each.If the signaling in the mesolimbic pathway is implicated by drug abuse, given what you know about other dopamine circuitsof the brain, what's the reason signaling in mesolimbic pathway can't just be blocked to reduce drug taking behavior?What cell receptor does adrenaline reach
- Naloxone works because it blocks receptors that usually bind with a. Endogenous opioids b. Heroine c. Opium d. Morphine e. All of these f. None of thesePeptide hormones interact with what structures on the surface of acell?a. receptor proteinsb. second messenger systemsc. pheromonesd. neurotransmitterse. digestive enzymesWhy might it be an advantage for an animal to produce its own pain-suppressing molecules?